Your guide to sales outlooks and R&D for treating Parkinson's
Where are treatments for Parkinson's disease heading – technological and commercial outlooks? Visiongain's updated report gives you forecasted revenues to 2023 and shows you R&D trends, opportunities and industry prospects. Emerging technologies hold promise.
Our new study investigates developments, also letting you assess projected sales data at overall world market, submarket and national level. There you investigate the most promising areas in that industry and market segment for neurodegenerative disorders.
Forecasts and other analyses to help you stay ahead in knowledge
In our report you find revenue forecasting to 2023, growth rates and market shares. Also, you see qualitative analysis (SWOT), business news, outlooks and developmental trends (R&D). You receive 63 tables, 38 charts and four research interviews.
You can stay ahead in knowledge for treating that motor system disorder and benefit your research and analyses. Our work lets you discover industry dynamics and growth potentials.
Make sure you know the latest trends, innovations and opportunities. The following sections show what you find in our study.
You see prospects for the world market and submarkets
Along with predictions of overall world market value, you see revenue forecasting of five submarkets at world level. We show sales data from 2011 to 2023:
• Dopaminergic agents
• Dopamine receptor agonists
• COMT inhibitors
• MAO inhibitors
• Other mechanisms of action (grouped).
With our investigation you gain research and analysis with individual sales forecasts and discussions. You find competition, commercial drivers and restraints. See what's likely to achieve the most success for treating Parkinson's disease (PD).
Our work also breaks the overall world PD forecast into leading national markets.
Prospects to 2023 for leading countries
Developments worldwide will influence the Parkinson's drug market, especially rising demand in emerging countries. There are many opportunities.
You discover individual revenue forecasts to 2023 for seven national markets and one developing market block. Find relevant overall sales:
• US
• Japan
• Germany, France, UK, Italy and Spain (EU5 countries)
• Brazil, Russia, India and China (BRIC nations, grouped analysis).
See what's likely to happen. You find areas with highest potential. Also, you investigate reasons for expected revenue growth, especially future PD medication.
Research and development – see trends and possibilities
What about the R&D pipeline for Parkinson's treatment? You assess developmental trends there:
• Adenosine receptor antagonists
• Glutamatergic drugs
• LID treatment options
• Agents for non-motor symptoms
• Treatment of psychosis
• Alleviation of PD sleep disorders
• Pain treatment
• Nicotinic receptor targeting.
Also, our work covers the disease modification field, including:
• Possible neuroprotectants (including Azilect)
• Biomarkers
• GDNF and other growth factors
• Peptide drugs
• Gene therapies
• Neurotrophic factors and PD treatment with stem cells
• Therapeutic vaccines.
Many opportunities exist for large companies and specialty pharma firms. Our study shows you why and how.
Leading companies and market value in 2016
What will happen next? The pharmaceutical industry will improve treatments for Parkinson's and other neurodegenerative disorders. The R&D pipeline is strong, broad and promising.
Overall world revenue for drugs treating PD will reach $3426m in 2016, our report forecasts. Ageing populations will increase sales of those medicines. Also, improved understanding of the disease, drug delivery and other technological advances will be important.
In our study you find discussions of these companies and others:
• Novartis
• GlaxoSmithKline (GSK)
• Newron
• Teva
• Addex
• Abbott.
Neurological specialists will develop and prosper from 2013. Our work shows you commercial possibilities for those CNS treatments.
Eight main ways Parkinson's Disease: World Drug Market 2013-2023 helps you
In particular, then, our investigation gives you the following knowledge on the topic:
• Forecasted revenues to 2023 for the overall world market and 5 submarkets – you discover the industry's future prospects
• Market forecasting to 2023 for US, Japan, Germany, France, UK, Spain, Italy and BRIC nations – you see national and regional sales outlooks
• Review of R&D pipelines – you hear about progress in established and emerging research areas and see commercial possibilities
• Opinions on the sector – you discover our interviews with authorities in the field
• Assessment of companies – you find activities, products, strategies and outlooks
• Competition and opportunities influencing sales – you see what affects the future
• Discussions of what stimulates and restrains the industry and market – you assess commercial trends, drivers and restraints
• Prospects for established firms and those seeking to enter the sector – you see factors and outlooks for success.
You gain information found nowhere else
That work gives independent analysis from our primary and secondary research. You receive business intelligence found only in our study, seeing where prospects are lucrative.
With our report you are less likely to fall behind in knowledge or miss opportunity. See how you could benefit your research, analyses and decisions, saving time and getting you recognition for technological and commercial insight.
Discover prospects for Parkinson's treatments by ordering now
Visiongain's study is for everyone needing analysis of the industry and market for treating neurodegenerative disorders. You find data, trends and predictions. Please ask for our report now.
Visiongain is a trading partner with the US Federal Government
CCR Ref number: KD4R6
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1. Executive Summary
1.1 Parkinson's Disease: Market Overview
1.2 Contents of this Report
1.3 Research and Analysis Methods
2. Parkinson's Disease: Overview
2.1 Parkinson's is Characterised by Dopamine Depletion
2.2 Motor Symptoms of Parkinson's Disease
2.2.1 Tremor
2.2.2 Rigidity
2.2.3 Bradykinesia
2.2.4 Postural Instability
2.2.5 Other Motor Symptoms
2.3 Cognitive, Behavioural and Other Symptoms
2.3.1 Cognitive Deficits
2.3.2 Behavioural and Mood Difficulties
2.3.3 Other Symptoms
2.4 Subtypes and Possible Origin of the Disease
2.5 Timeline of Parkinson's Disease Treatment
3. Parkinson's Disease Treatment: Market Overview 2013-2023
3.1 How Much Growth Can Be Expected in the Parkinson's Disease Market, 2013-2023?
3.1.1 Overall Market Forecast for 2012-2023
3.2 Three Franchises Held 60% of the Market in 2011
3.2.1 Mirapex Drops Back in 2011
3.2.2 Patent Protection is Nearly at an End for the Leading Drugs
3.2.3 Important Generic Launches in 2011-2012
3.3 The Three Market Leaders: Overview
3.3.1 Comtan/Stalevo: Leading Parkinson's Disease Drug
3.3.2 Requip: Leading the Dopamine Agonist Segment
3.3.3 Azilect: Set to Become Market Leader
3.3.3.1 Azilect: The First Neuroprotectant?
3.4 Leading Companies in the Parkinson's Disease Treatment Market
4. Leading National Markets, 2013-2023
4.1 The EU5 Represented the Largest Regional Parkinson's Disease Market in 2011
4.2 The BRIC Nations Will Be the Fastest-Growing Region in the Forecast Period
4.3 The US Represents a Quarter of the Market
4.3.1 Market Projection for the US, 2012-2023
4.4 EU5: Ageing Populations and Fiscal Restrictions
4.4.1 Market Projection for the EU5 Group, 2012-2023
4.4.2 Breakdown of the EU5 by Country, 2011
4.4.3 Changes in Market Shares of the EU5 Countries, 2012-2023
4.4.4 Germany 2012-2023: The Largest EU5 Market
4.4.5 France 2012-2023: EU5's Highest Healthcare Spender
4.4.6 UK 2012-2023: Spending Restrictions
4.4.7 Spain 2012-2023: Facing Significant Cost-Containment Measures
4.4.8 Italy 2012-2023: One in Five People Are Over 65
4.5 Japan 2012-2023: Second-Largest National Market in 2012
4.5.1 Market Projection for Japan, 2012-2023
4.6 BRIC Nations: The Rapid-Growth Area for Pharma
4.6.1 Market Projection for the BRIC Nations Group 2012-2023
5. Market Segments for Treatment of Parkinson's Disease, 2013-2023
5.1 Dopamine Receptor Agonists: the Leading Class of Drug in 2011
5.2 How Will the Balance of Market Share Shift During the Forecast Period?
5.3 Dopaminergic Agents: The Foundation of Parkinson's Disease Treatment
5.3.1 Levodopa and Carbidopa
5.3.2 Brands of Dopaminergic Agent
5.3.3 Use of Dopaminergic Agents Will Remain Central to Parkinson's Disease Management
5.3.4 A New Commercial Life for Dopaminergic Agents?
5.3.5 Market Projection for Dopaminergic Agents, 2012-2023
5.4 Dopamine Receptor Agonists: The Leading Class in 2011
5.4.1 Mechanism of Action Makes Dopamine Receptor Agonists a Good First-Line Therapy
5.4.2 Multiple Products Exist in the Dopamine Receptor Agonists Class
5.4.3 A Thin Pipeline in this Segment
5.4.4 Commercial Opportunities for Dopamine Receptor Agonists
5.4.5 Market Projection for Dopamine Receptor Agonists, 2012-2023
5.5 COMT Inhibitors: The Segment with the Leading Product in 2011
5.5.1 COMT Inhibitors as Adjuncts to Dopaminergic Agents
5.5.2 Limitations of COMT Inhibitors
5.5.3 Future Commercial Scope for COMT Inhibitors
5.5.4 Market Projection for COMT Inhibitors, 2012-2023
5.6 MAO Inhibitors: A Growing Segment
5.6.1 Another Useful Adjunct to Levodopa
5.6.2 MAO Inhibitors Have Advantages over COMT Inhibitors
5.6.3 Potential for New Growth in the Sector
5.6.4 Market Projection for MAO Inhibitors (Orient Pharma): Treatment for Sialorrhoea
6.22 Sialorrhoea: A Socially Difficult Symptom of PD
6.23 NH004 (NeuroHealing)
6.24 VR040 (Vectura Group)
6.25 XP21279 (XenoPort)
6.26 The Phase 1 and Preclinical Pipeline: Overview
6.26.1 ND0611 (Neuroderm)
6.27 Neu-120 (Neurim Pharmaceuticals)
6.28 Ordopidine (Neurosearch)
6.29 ProNeura Continuous Release Dopamine Agonist (Titan Pharmaceuticals)
6.30 V81444 (Vernalis): Regained Rights from Biogen Idec
6.31 AVE8112 (Sanofi/MJFF)
6.32 SKL-PD (SK Biosciences)
7. The Next Frontier in PD Treatment: Disease-Modifying Treatments R&D Pipeline
7.1 Disease Modification and Neuroprotection: Basic Concepts
7.1.1 Why Do Cells Die in PD and What Would Stop Them?
7.2 Azilect: the Leading Candidate Neuroprotectant Among Existing Approved Drugs
7.2.1 Azilect's Presumed Neuroprotective Mechanisms of Action
7.2.2 How can Neuroprotective Effects be Measured?
7.2.3 Early Interventions and Delayed Starts
7.2.4 'This is Close, But It's Not Good Enough': The ADAGIO Trial Verdict
7.2.5 Where Does the Failure of the Azilect Trial Leave the Disease Modification Concept?
7.3 How Will We Know Disease Modification if We See It? Progress in Biomarkers, Imaging and Disease Models
7.3.1 The $30m Search for PD Biomarkers
7.3.2 When Will We Have Robust PD Biomarkers?
7.3.3 Players in the PD Biomarkers Field
7.3.4 SPECT, PET and MRI: Shining a Light on PD
7.3.5 Disease Process, not Disease Endstage: New Animal Models for Disease Modification
7.4 Candidates for Disease Modification: Pipeline Overview
7.5 Coenzyme Q10 (National Institute of Neurological Disorders and Stroke [NINDS])
7.5.1 A Nutritional Supplement with Limited Commercial Scope
7.5.2 Nearly Two Decades of Investigation
7.5.3 Dietary Supplements as Disease Modifiers
7.6 Repurposing Existing Drugs for PD
7.7 Exenatide (University College London)
7.7.1 Rationale for Repurposing Exenatide
7.8 Isradipine (The Parkinson Study Group)
7.8.1 Blocking Brain Calcium Channels
7.9 Other Possible Small-Molecule Disease-Modifying Agents
7.10 Cogane (Phytopharm)
7.10.1 Cogane's Possible Disease-Modification Mechanism
7.10.2 One of the Leading Small Molecules in the Disease Modification Hunt
7.11 AZD3241 (AstraZeneca): First Myeloperoxidase Inhibitor in PD Trials
7.12 AT2101/AT3375 (Amicus Therapeutics): Innovative 'Pharmacological Chaperone'
7.13 VAR 10300 (Varinel): Virtual Company's Possible PD Candidate
7.13.1 Multiple Mechanisms of Action
7.14 NP001 (Neuraltus)
7.15 XP23829 (XenoPort): A Promising Prodrug
7.16 GDNF and Other Growth Factors: A Neglected Possibility?
7.17 MANF (Amarantus BioSciences): A Future Biological Blockbuster?
7.18 Peptide Drugs
7.19 GM6 (Genervon Biopharmaceuticals)
7.19.1 Impressive Animal Model Results
7.20 NNZ-2591 (Neuren Pharmaceuticals)
7.21 Davunetide (Allon Therapeutics)
7.22 Gene Therapies
7.23 ProSavin (Oxford BioMedica)
7.23.1 ProSavin Clinical Trials Performance to Date
7.23.2 Will ProSavin Lead The Charge In PD Gene Therapy?
7.24 CERE-120 (Ceregene): Delivering Neurotrophic Factors
7.24.1 Repairing Dopaminergic Neurons in Human Beings
7.24.2 Can New Trial Succeed Where Past Attempts Failed?
7.25 AAV-hAADC-2 (Genzyme): AAV Gene Therapy Due to Complete Phase 1 in Q1 2013
7.26 Collategene (Vical/AnGes): Angiogenic Gene Therapy
7.27 AAV2-GDNF (uniQure)
7.28 Cellular Therapies
7.29 Spheramine (Bayer): RPE Cells to Make Levodopa
7.30 NTCELL (Living Cell Technologies)
7.31 Stem Cell Approaches to PD
7.32 NeuroGeneration - PD Treatment with Autologous Neural Stem Cells
7.33 BrainStorm Cell Therapeutics - Proprietary NurOwn Cells
7.34 Therapeutic Vaccine Approaches
7.35 Affitope PD01 (Affiris) - The First Vaccine for PD
8. Qualitative Industry Ana$m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.13 France: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.14 France: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.15 UK: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.16 UK: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.17 Spain: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.18 Spain: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.19 Italy: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.20 Italy: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.21 Japan: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.22 Japan: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 4.23 BRIC Nations: Grouped Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 4.24 BRIC Nations: Grouped Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.1 PD Market Breakdown by Segment: Revenues ($m), Market Shares (%), 2011
Table 5.2 PD Market Breakdown by Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 5.3 PD Market Breakdown by Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.4 Selected Dopaminergic Agents, 2012
Table 5.5 Dopaminergic Agents Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%) 2011-2016
Table 5.6 Dopaminergic Agents Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.7 Selected Dopamine Receptor Agonists, 2012
Table 5.8 Dopamine Receptor Agonists Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 5.9 Dopamine Receptor Agonists Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.10 COMT Inhibitors Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 5.11 COMT Inhibitors Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.12 MAO Inhibitors Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 5.13 MAO Inhibitors Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 5.14 Other Mechanisms of Action Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2011-2016
Table 5.15 Other Mechanisms of Action Segment: Revenues ($m), AGR (%), CAGR (%), Market Shares (%), 2017-2023
Table 6.1 Selected Phase 3 PD Pipeline, 2012
Table 6.2 Reformulations of Levodopa and Other Dopaminergic Agents in Pipeline Development, 2012
Table 6.3 Pipeline Candidates with Established Mechanisms of Action, 2012
Table 6.4 Pipeline Adenosine 2a Receptor Antagonists, 2012
Table 6.5 Pipeline Candidates for Non-Motor PD Symptoms, 2012
Table 6.6 Pipeline Candidates for Motor PD Symptoms, 2012
Table 6.7 Pipeline Glutamatergic Drugs, 2012
Table 6.8 Selected Phase 2 PD Pipeline, 2012
Table 6.9 Pipeline Nicotine Receptor Agonists, 2012
Table 6.10 Allosteric Modulators in Development for PD, 2012
Table 7.1 Trials of PD Drugs as Neuroprotectants, 2012
Table 7.2 Selected Possible Disease-Modifying Agents under Investigation in PD, 2012
Table 7.3 Selected Dietary Supplements in the PD Pipeline, 2012
Table 7.4 Selected Repurposed Drugs in the PD Pipeline, 2012
Table 7.5 Selected Small-Molecule Drugs in the PD Pipeline, 2012
Table 7.6 Selected Peptide Drugs in the PD Pipeline, 2012
Table 7.7 Selected Gene Therapies in the PD Pipeline, 2012
Table 7.8 Selected Cellular Therapies in the PD Pipeline, 2012
List of Figures
Figure 2.1 The Five Stages of Parkinson's Disease
Figure 3.1 PD Market: Revenues ($m), 2011-2023
Figure 3.2 PD Market: Leading Drugs, Revenues ($m), Market Shares (%), 2011
Figure 3.3 Azilect: Projected PD Market Shares (%), 2013-2023
Figure 3.4 PD Market: Leading Companies, Revenues ($m), Market Shares (%), 2011
Figure 4.1 PD Market Breakdown by Region: Revenues ($m), Market Shares (%), 2011
Figure 4.2 PD Market Breakdown by Region: Revenues ($m), 2011-2023
Figure 4.3 US Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.4 US Region: Revenues ($m), 2011-2023
Figure 4.5 EU5 Region: Revenues ($m), 2011-2023
Figure 4.6 EU5 Region Breakdown by Country: Revenues ($m), Market Shares (%), 2011
Figure 4.7 EU5 Breakdown by Country: Revenues ($m), 2011-2023
Figure 4.8 Germany: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.9 Germany Region: Revenues ($m), 2011-2023
Figure 4.10 France: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.11 France: Revenues ($m), 2011-2023
Figure 4.12 UK: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.13 UK: Revenues ($m), 2011-2023
Figure 4.14 Spain: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.15 Spain: Revenues ($m), 2011-2023
Figure 4.16 Italy: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.17 Italy: Revenues ($m), 2011-2023
Figure 4.18 Japan: Over-65 Population as Percentage of Overall Population, 2011-2023
Figure 4.19 Japan: Revenues ($m), 2011-2023
Figure 4.20 BRIC Nations: Grouped Revenues ($m), 2011-2023
Figure 5.1 PD Market Breakdown by Segment: Revenues ($m), Market Shares (%), 2011
Figure 5.2 PD Market Breakdown by Segment: Revenues ($m), 2011-2023
Figure 5.3 Drivers and Restraints for Dopaminergic Agents, 2012
Figure 5.4 Dopaminergic Agents Segment: Revenues ($m), 2011-2023
Figure 5.5 Drivers and Restraints for Dopamine Receptor Agonists, 2012
Figure 5.6 Dopamine Receptor Agonists Segment: Revenues ($m), 2011-2023
Figure 5.7 Drivers and Restraints for COMT Inhibitors, 2012
Figure 5.8 COMT Inhibitors Segment: Revenues ($m), 2011-2023
Figure 5.9 Drivers and Restraints for MAO Inhibitors, 2012
Figure 5.10 MAO Inhibitors Segment: Revenues ($m), 2011-2023
Figure 5.11 Other Mechanisms of Action Segment: Revenues ($m), 2011-2023
Figure 10.1 PD Market: Overall Revenues ($m), 2011, 2016 and 2023
Figure 10.2 PD Market Revenues by Segment ($m), 2011, 2016 and 2023
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Abbott Laboratories
Acadia Pharmaceuticals
Adamas Pharmaceuticals
Addex Therapeutics
Affiris
Allon Therapeutics
Amarantus BioSciences
Amgen
Amicus Therapeutics
Amylin Pharmaceuticals
AnGes
Ark Therapeutics
AstraZeneca
Axxonis Pharma
Bayer
BIAL - Portela
Biogen Idec
Bioprojet Pharma
BioSante Pharmaceuticals
Biotie Therapies
Biovail
Boehringer Ingelheim
BrainStorm Cell Therapeutics
Buck Institute for Research on Ageing
Ceregene
Chelsea Therapeutics
Ciba-Geigy
Cipla
Civitas Therapeutics
Columbia University
Dainippon Sumitomo
Dendreon
Depomed
DiaGenic
Domain Therapeutics
Dr. Reddy's Laboratories
Dresden University of Technology
Durin Technologies
Eisai
EMD Serono
Endo Pharmaceuticals
Erba
European Medicines Agency (EMEA/EMA)
Farmitalia Carlo
Food and Drug Administration (US FDA)
Genervon Biopharmaceuticals
Genzyme
GlaxoSmithKline (GSK)
Impax Pharmaceuticals (Impax Laboratories)
Intec Pharma
Ipsen
Juvantia Pharma
Kaneka Nutrients
Kyoto University
Kyowa Hakko Kirin
Living Cell Technologies
Lundbeck
Maypro Industries
Meiji Seika
Merck & Co.
Merck KGaA
Merck Serono
Mitsubishi Gas Chemical
Mount Sinai School of Medicine
Mundipharma Research
Mylan
Napp Pharmaceuticals
National Health Service (NHS, UK)
National Institute for Health and Clinical Excellence (NICE, UK)
National Institute of Neurological Disorders and Stroke (NINDS, US)
National Institutes of Health (NIH, US)
Neupro
Neuraltus
Neuren Pharmaceuticals
Neurim Pharmaceuticals
Neuroderm
NeuroGeneration
NeuroHealing
Neurologix
NeuroSearch
Newron
Novartis
NsGene
Orient Pharma
Orion
Oxford BioMedica
Pacific Rainbow International
Parkinson's UK
Parr
Pfizer
Pharmacia
Phytopharm
Power3 Medical Products
Roche
Roxane
Sandoz
Sanofi
Santhera
Schering Plough
Servier
ShenZhou Biology & Technology
SK Biosciences
Solvay Pharmaceuticals
Sun
Swedish Orphan Biovitrum
Synergen Corporation
Synosia Therapeutics
Technion-Israel Institute of Technology
Tel Aviv University
Teva Pharmaceutical Industries
The Michael J. Fox Foundation
Titan Pharmaceuticals
UCB
uniQure
University College London (UCL)
University of Bristol Institute of Clinical Neuroscience
University of California, Los Angeles (UCLA)
University of Kentucky
University of Nebraska
University of Rochester
Valeant
Varinel
Vectura Group
Vernalis
Vical
Watson Pharmaceuticals
Wockhardt
XenoPort
Xiamen Kingdomway Group
Zambon
Zhejiang Medicine Company
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