1. Report Overview
1.1 World IBD Drugs Market: Overview of Findings
1.2 Why You Should Read This Report
1.3 How the Study Delivers
1.4 Main Questions Covered in the Analysis
1.5 Who is this Report For?
1.6 Methods of Research and Analysis
1.6.1 Primary Research
1.6.2 Secondary Research
1.6.3 Market Evaluation and Forecasting Methods
1.7 Frequently Asked Questions (FAQ)
1.8 Associated Reports
1.9 About Visiongain
2. Introduction to the Inflammatory Bowel Disease Drug Market
2.1 What is Inflammatory Bowel Disease (IBD)?
2.2 Classification of IBD
2.3 Symptoms and Diagnosis of IBD
2.4 Multifactorial Causes of IBD
2.5 How Common is IBD?
2.6 What Are the Treatment Options for IBD?
2.6.1 Aminosalicylates - The Most Common Therapy
2.6.2 Antibiotics - Will There Be Any Supporting Evidence Soon?
2.6.3 Corticosteroids - Uptake from Uceris?
2.6.4 Immunomodulators - Slow to Act?
2.6.5 Monoclonal Antibodies - Not Cost-effective?
2.7 Treatment Goals for IBD - Treat-to-Target Approach?
2.8 Treatment Algorithm - is Top-Down Approach the Future Direction?
3. The World Inflammatory Bowel Disease Drug Market, 2018-2028
3.1 The Inflammatory Bowel Disease Market in 2016 and 2017
3.2 Forecast 2018-2028: Impacted by Biosimilars?
3.3 Biologic Therapies Forecast 2018-2028 - Driving the Market
3.4 Aminosalicylates Forecast 2018-2028: The steady decline
3.5 Antibiotics Forecast 2018-2028: Growing Despite Challenges
3.6 Corticosteroids Forecast 2018-2028: Driven by Uceris
3.7 Immunomodulators Forecast 2018-2028 - Will Slowly Lose Market Share
4. Market Prospects for Leading IBD Drugs, 2018-2028
4.1 Humira (AbbVie) - Growing in the First Half of Forecast Period
4.1.1 Humira: Forecast and Analysis, 2018-2028
4.2 Remicade (Janssen Biotech) - Will Slowly Be Eroded by Biosimilars
4.2.1 Remicade: Forecast and Analysis, 2018-2028
4.3 Asacol (Allergan) - Threat from Generic Competition
4.3.1 Asacol: Forecast and Analysis, 2018-2028
4.4 Pentasa (Shire) - Differentiated by Its Delivery System
4.4.1 Pentasa: Forecast and Analysis, 2018-2028
4.5 Lialda (Shire) - Will Improved Compliance Increase Revenue?
4.5.1 Lialda: Forecast and Analysis, 2018-2028
4.6 Tysabri (Perrigo) - Still Protected by Patent
4.6.1 Tysabri: Forecast and Analysis, 2018-2028
4.7 Xifaxan (Valeant) - Still Growing Significantly
4.7.1 Xifaxan: Forecast and Analysis, 2018-2028
4.8 Cimzia (UCB) - How Will It Fare Against Biosimilars?
4.8.1 Cimzia: Forecast and Analysis, 2018-2028
4.9 Entocort (AstraZeneca) - A Slow and Steady Decline?
4.9.1 Entocort: Forecast and Analysis, 2018-2028
4.10 Neoral (Novartis) - Will its Side Effect Profile Hamper Sales Growth?
4.10.1 Neoral: Forecast and Analysis, 2018-2028
4.11 Medrol (Pfizer) - Another Leading Steroid
4.11.1 Medrol: Forecast and Analysis, 2018-2028
4.12 Canasa (Allergan) - Will a Generic Competitor Soon Be Available?
4.12.1 Canasa/Salofalk: Forecast and Analysis, 2017-2027
4.13 Apriso (Valeant) - Challenger to Asacol?
4.13.1 Apriso: Forecast and Analysis, 2018-2028
4.14 Azulfidine (Pfizer) - Tried, Tested and Staying in the Market
4.14.1 Azulfidine: Forecast and Analysis, 2018-2028
4.15 Entyvio (Takeda Pharmaceuticals) - Driving the Biologics Segment
4.15.1 Entyvio: Forecast and Analysis, 2018-2028
4.16 Simponi (Janssen Biotech) - Rising Star for the Market?
4.16.1 Simponi: Forecast and Analysis, 2018-2028
4.17 Uceris (Valeant) - Meeting Patients' Needs with Its Delivery System
4.17.1 Uceris: Forecast and Analysis, 2018-2028
5. Leading National Markets: Sales Outlooks, 2017-2027
5.1 IBD Drugs - Leading National Markets 2017
5.2 The US IBD Drug Market, 2018-2028 - The World Leader
5.3 The Japanese IBD Drug Market, 2018-2028 - Growing Significantly?
5.4 The EU-5 IBD Drug Market, 2018-2028 - Driven by the UK
5.4.1 The German IBD Drug Market, 2018-2028
5.4.2 The French IBD Drug Market, 2018-2028
5.4.3 The UK IBD Drug Market, 2017-2027
5.4.4 The Spanish IBD Drug Market, 2017-2027
5.4.5 The Italian IBD Drug Market, 2018-2028
5.5 IBD Drug Markets in BRIC Countries - Taking More Market Share
5.5.1 The Brazilian IBD Drug Market, 2018-2028
5.5.2 The Russian IBD Drug Market, 2018-2028
5.5.3 The Indian Drug Market, 2018-2028
5.5.4 The Chinese IBD Drug Market, 2018-2028
6. The R&D Pipeline for Inflammatory Bowel Disease, 2017
6.1 Top Marketed and pipeline products - Launch dates and Patent expiry
6.2 Interleukin (IL) Inhibitors - One of the Main Areas of Innovation
6.2.1 CyCol (Sigmoid Pharma)
6.2.2 PF-04236921 (Pfizer)
6.2.3 QAX 576 (Novartis)
6.2.4 TNF Kinoid (Neovacs)
6.2.5 Vidofludimus (4SC) - Suspended
6.2.6 Stelara (Ustekinumab, CNTO 1275, Janssen Biotech)
6.3 Cell-Adhesion Molecule (CAM) Inhibitors - A Promising Avenue
6.3.1 AJG 511 (Ajinomoto Pharmaceutical Co.)
6.3.2 AJM 300 (Ajinomoto Pharmaceuticals)
6.3.3 MEDI 7183/AMG 181 (AstraZeneca)
6.3.4 Etrolizumab (Roche)
6.3.5 PF-00547659 (Pfizer)
6.3.6 Alicaforsen (ISIS 2302, Atlantic Healthcare)
6.3.7 MEDI-2070/AMG 139 (AstraZeneca & Amgen)
6.4 TNF-α Inhibitors - a Specific Target
6.4.1 AVX-470 (Avaxia Biologics)
6.4.2 Ozoralizumab (ALX-0061, Ablynx)
6.5 Stem Cell Therapies - Basis for a Cure?
6.5.1 Ovasave (TxCell)
6.5.2 MultiStem (Athersys and Pfizer)
6.5.3 Prochymal (Remestemcel-L, Osiris Therapeutics)
6.5.4 Cx601 (TiGenix)
6.6 JAK Inhibitors - New Target Pathway
6.6.1 JNJ-54781532 (Janssen)
6.6.2 Xeljanz, (Tofacitinib, CP-690550, Pfizer)
6.7 Toll-like Receptor Agonists
6.7.1 BL-7040 (BioLineRX)
6.7.2 Kappaproct (InDex Pharmaceuticals)
6.8 Other Classes of Agent
6.8.1 Trichuris suis ova (CNDO-201, Coronado Biosciences)
6.8.2 GLPG0974 (Galapagos)
6.8.3 RPC1063 (Receptos/now Celgene)
6.8.4 SGX203 (Soligenix)
6.8.5 Mongersen (GED-0301, Celgene)
6.8.6 Tetomilast (OPC-6535, Otsuka)
6.8.7 Laquinimod (Active Biotech)
6.8.8 RHB-104 (RedHill Biopharma)
6.8.9 Ozanimod (Celgene)
6.8.10 GED-0301 (Celgene)
6.9 Biosimilar Candidates - Promising Competitors of Leading Biologics
6.9.1 Adalimumab Biosimilars
6.9.2 Infliximab Biosimilars
7. Qualitative Analysis of the Inflammatory Bowel Disease Drug Industry and Market, 2017
7.1 SWOT and STEP Analysis of the IBD Drugs Market
7.2 What Factors Will Stimulate the IBD Market?
7.2.1 Increasing Disease Incidence in Most National Markets
7.2.2 Better Diagnosis - Early Referrals
7.2.3 Delivery Systems Improve Existing Drugs
7.2.4 Biological Drugs - Driving the Market Significantly
7.2.5 Socioeconomic Costs of IBD
7.3 What Factors Will Restrain the Market?
7.3.1 Lack of Understanding of Disease Aetiology
7.3.2 Compliance - Frequent Dosing is Inconvenient
7.3.3 Limitations of Biologics - Side Effect Profiles
7.3.4 The Possible Development of Alternative Treatments
7.3.5 Surgery - Treatment for Recalcitrant IBD
7.3.6 Health Care Cost Containment
8. Leading Companies in the IBD Pharmaceuticals Market, 2017
8.1 The Largest Companies by Revenue
8.1.1 AbbVie
8.1.2 Janssen Biotech
8.1.3 Allergan
8.1.4 Shire Pharmaceuticals
8.1.5 Takeda Pharmaceuticals
9. Conclusions of the Study
9.1 The IBD Drugs Market Will Expand from 2018 to 2028
9.2 Aminosalicylates and Other Non-Biologic Treatments
9.3 Biological Treatments Dominate the Market
9.4 Improvements Needed in IBD Therapy
9.5 Future IBD Treatments: R&D Efforts Look Promising
9.6 The IBD Sector: Looking to the Future with Confidence
Appendices
Associated Visiongain Reports
Visiongain Report Sales Order Form
About Visiongain
Visiongain Report Evaluation Form
List of Tables
Table 2.1 Differentiating Crohn's Disease and Ulcerative Colitis
Table 2.2 Worldwide Prevalence Rates for IBD, 2016
Table 2.3 Worldwide Incidence Rates for IBD, 2016
Table 2.4 Geographical Variations in the Incidence of IBD, 2016
Table 2.5 Other Drug Types Used to Treat IBD, 2016
Table 2.6 Treatment Protocol for IBD, 2016
Table 3.1 Global IBD Drug Sales ($m), Annual Growth Rates (%) and Market Shares (%) by Segment, 2016 and 2017
Table 3.2 Global IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.3 Global IBD Drug Forecast by Drug Category: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.4 Global IBD Drug Market Drivers and Restraints 2018-2028
Table 3.5 Global Biologics Forecast for IBD Market: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.6 Global Biologic Therapies Drivers and Restraints, 2018-2028
Table 3.7 Global Aminosalicylates Forecast for IBD Market: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.8 Global Aminosalicylates Drivers and Restraints, 2018-2028
Table 3.9 Global Antibiotics Forecast for IBD Market: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.10 Global Antibiotics Drivers and Restraints, 2018-2028
Table 3.11 Global Corticosteroids Forecast for IBD Market: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.12 Global Corticosteroids Drivers and Restraints, 2018-2028
Table 3.13 Global Immunomodulators Forecast for IBD Market: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 3.14 Global Immunomodulators Drivers and Restraints, 2018-2028
Table 4.1 Leading IBD Treatments by Revenue ($m), 2017
Table 4.2 Leading IBD Medicines: Revenue Forecasts ($m), AGR (%), 2018-2028
Table 4.3 World Humira Revenue Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.4 Drivers and Restraints for Humira, 2018-2028
Table 4.5 World Remicade Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.6 Drivers and Restraints for Remicade, 2018-2028
Table 4.7 World Asacol Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.8 Drivers and Restraints for Asacol, 2018-2028
Table 4.9 World Pentasa Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.10 Drivers and Restraints for Pentasa, 2018-2028
Table 4.11 World Lialda Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.12 Drivers and Restraints for Lialda, 2018-2028
Table 4.13 World Tysabri Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.14 Drivers and Restraints for Tysabri, 2018-2028
Table 4.15 World Xifaxan Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.16 Drivers and Restraints for Xifaxan, 2018-2028
Table 4.17 World Cimzia Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.18 Drivers and Restraints for Cimzia, 2018-2028
Table 4.19 World Entocort Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.20 Drivers and Restraints for Entocort, 2018-2028
Table 4.21 World Neoral Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.22 Drivers and Restraints for Neoral, 2018-2028
Table 4.23 World Medrol Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 4.24 Drivers and Restraints for Medrol, 2018-2028
Table 4.25 World Canasa Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.26 Drivers and Restraints for Canasa, 2018-2028
Table 4.27 World Apriso Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.28 Drivers and Restraints for Apriso, 2018-2028
Table 4.29 World Azulfidine Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.30 Drivers and Restraints for Azulfidine, 2018-2028
Table 4.31 World Entyvio Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 4.32 Drivers and Restraints for Entyvio, 2018-2028
Table 4.33 World Simponi Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.34 Drivers and Restraints for Simponi, 2018-2028
Table 4.35 World Uceris Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 4.36 Drivers and Restraints for Uceris, 2018-2028
Table 5.1 IBD Drug Revenues ($m) by Leading Country, 2017
Table 5.2 US IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 5.3 Japanese IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 5.4 EU5 IBD Drug Market Forecasts: Revenues ($m), AGR (%), CAGR (%), 2018-2023
Table 5.5 EU5 IBD Drug Market Forecasts: Revenues ($m), AGR (%), CAGR (%), 2023-2028
Table 5.6 German IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 5.7 French IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 5.8 UK IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 5.9 Spanish IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 5.10 Italian IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 5.11 BRIC IBD Drug Market Forecasts: Revenues ($m), AGR (%), CAGR (%), 2018-2023
Table 5.12 BRIC IBD Drug Market Forecasts: Revenues ($m), AGR (%), CAGR (%), 2023-2027
Table 5.13 Brazilian IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 5.14 Russian IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 5.15 Indian IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2016-2027
Table 5.16 Chinese IBD Drug Market Forecast: Revenues ($m), AGR (%), CAGR (%), 2018-2028
Table 6.1 Key Patent dates for marketed and pipeline products
Table 6.2 Selected IL Inhibitors in Clinical Development, 2018
Table 6.3 Selected CAM Inhibitors in Clinical Development, 2018
Table 6.4 Selected TNF-α Inhibitors in Clinical Development, 2018
Table 6.5 Selected Stem Cell Therapies in Clinical Development, 2018
Table 6.6 Selected JAK Inhibitors in Clinical Development, 2018
Table 6.7 Selected Toll-like Receptor Agonist in Clinical Development, 2018
Table 6.8 Selected Other Classes in Clinical Development, 2018
Table 7.1 Strengths, Weaknesses, Opportunities and Threats in the IBD Drug Market
Table 7.2 Social, Technological, Economic and Political Forces on the IBD Drug Market
Table 8.1 AbbVie Revenues ($m) and Market Share (%), 2017
Table 8.2 Janssen Biotech Revenues ($m) and Market Share (%), 2017
Table 8.3 Allergan Revenues ($m) and Market Share (%), 2017
Table 8.4 Shire Revenues ($m) and Market Share (%), 2017
Table 8.5 Takeda Revenues ($m) and Market Share (%), 2017
Table 9.1 Global IBD Revenue Forecasts ($m), Market Share (%) by Product Category, 2018, 2023, 2028
Table 9.2 Global IBD Revenue Forecasts ($m), CAGR (%) and Market Shares (%) by Region, 2018, 2023, 2028
Table 9.3 Summary of IBD Market Drivers and Restraints, 2018-2028
List of Figures
Figure 1.1 Inflammatory Bowel Disease Market Segmentation, 2017
Figure 3.1 World IBD Drugs Market Shares by Product Type (%), 2018
Figure 3.2 Global IBD Drug Market Forecast ($m), 2018-2028
Figure 3.3 World IBD Drugs Market Shares by Product Type (%), 2028
Figure 3.4 Global Biologics Forecast for IBD Market ($m), 2018-2028
Figure 3.5 Global Aminosalicylates Forecast for IBD Market ($m), 2018-2028
Figure 3.6 Global Antibiotics Forecast for IBD Market ($m), 2018-2028
Figure 3.7 Global Corticosteroids Forecast for IBD Market ($m), 2018-2028
Figure 3.8 Global Immunomodulators Forecast for IBD Market ($m), 2018-2028
Figure 4.1 World Humira Revenue Forecast ($m), 2018-2028
Figure 4.2 World Remicade Forecast ($m), 2018-2028
Figure 4.3 World Asacol Forecast ($m), 2018-2028
Figure 4.4 World Pentasa Forecast ($m), 2018-2028
Figure 4.5 World Lialda Forecast ($m), 2018-2028
Figure 4.6 World Tysabri Forecast ($m), 2018-2028
Figure 4.7 World Xifaxan Forecast ($m), 2018-2028
Figure 4.8 World Cimzia Forecast ($m), 2018-2028
Figure 4.9 World Entocort Forecast ($m), 2018-2028
Figure 4.10 World Neoral Forecast ($m), 2018-2028
Figure 4.11 World Medrol Forecast ($m), 2018-2028
Figure 4.12 World Canasa Forecast ($m), 2018-2028
Figure 4.13 World Apriso Forecast ($m), 2018-2028
Figure 4.14 World Azulfidine Forecast ($m), 2018-2028
Figure 4.15 World Entyvio Forecast ($m), 2018-2028
Figure 4.16 World Simponi Forecast ($m), 2018-2028
Figure 4.17 World Uceris Forecast ($m), 2018-2028
Figure 5.1 Global IBD Drug Market by Leading Country (%), 2018
Figure 5.2 Global IBD Drug Market by Leading Country (%), 2028
Figure 5.3 US IBD Drug Market Forecast ($m), 2018-2028
Figure 5.4 Japanese IBD Drug Market Forecast ($m), 2018-2028
Figure 5.5 EU5 IBD Drug Market Forecasts ($m), 2018-2028
Figure 5.6 German IBD Drug Market Forecast ($m), 2018-2028
Figure 5.7 French IBD Drug Market Forecast ($m), 2018-2028
Figure 5.8 UK IBD Drug Market Forecast ($m), 2018-2028
Figure 5.9 Spanish IBD Drug Market Forecast ($m), 2018-2028
Figure 5.10 Italian IBD Drug Market Forecast ($m), 2018-2028
Figure 5.11 BRIC IBD Drug Market Forecasts ($m), 2018-2028
Figure 5.12 Brazilian IBD Drug Market Forecast ($m), 2018-2028
Figure 5.13 Russian IBD Drug Market Forecast ($m), 2018-2028
Figure 5.14 Indian IBD Drug Market Forecast ($m), 2018-2028
Figure 5.15 Chinese IBD Drug Market Forecast ($m), 2018-2028
Figure 8.1 AbbVie Assets - Marketed and Pipeline 2016
Figure 8.2 AbbVie Deals and Partnerships 2011 - 2016
Figure 8.3 Janssen Assets - Marketed and Pipeline 2016
Figure 8.4 Janssen - Deals and Partnerships 2011 - 2016
Figure 8.5 Allergan Assets - Marketed and Pipeline 2016
Figure 8.6 Allergan - Deals and Partnerships 2011 - 2016
Figure 8.7 Shire Assets - Marketed and Pipeline 2016
Figure 8.8 Shire - Deals and Partnerships 2011 - 2016
Figure 8.9 Takeda Assets - Marketed and Pipeline 2016
Figure 8.10 Shire - Deals and Partnerships 2011 - 2015
