1. Executive Summary
1.1 Lyophilisation Market Review
1.2 Aims, Scope and Format of the Report
1.2.1 Chapter Outlines
1.3 Research and Analysis Methods
2. Introduction to Lyophilisation (Freeze Drying)
2.1 Introduction
2.1.1 What is Freeze Drying?
2.1.2 Why Freeze Dry?
2.1.3 A Brief History
2.2 General Description of the Process
2.2.1Freezing
2.2.2 Primary Drying (Sublimation)
2.2.3 Secondary Drying (Desorption)
2.3 Freeze Drying Equipment
2.3.1 Components of the Freeze Dryer
2.3.1.1 Drying Chamber
2.3.1.2 Condenser
2.3.1.3 Vacuum Pump
2.3.1.4 Refrigeration System
2.3.1.5 Control Facilities
2.4 Type of Freeze Dryers
2.4.1Rotary Freeze Dryers
2.4.2 Manifold Freeze Dryers
2.4.3 Tray Freeze Dryers
2.5 Applications of Lyophilisation
2.5.1 Pharmaceutical and Biotechnology Industry
2.5.2 Other Chemical and Technological Sectors
2.5.3 Veterinary Applications
2.5.4 Food Industry Applications
2.5.5 What Products Are Freeze Dried?
2.5.6 How do Freeze Dryers for Food Differ from those for Pharmaceutical Applications?
2.5.7 Other Applications for Lyophilisation
3. Lyophilisation Technology and Services Market, 2010-2021
3.1 Scope and Limitations
3.2 The World Lyophilisation Technology and Services Market in 2010
3.2.1 Marketed Lyophilised Drugs, 2010
3.2.2 Total Lyophilisation Market was Worth $1.99bn in 2010
3.3 Sales Forecast for Overall Lyophilisation Market, 2010-2015
3.4 Sales Forecast for Overall Lyophilisation Market, 2016-2021
3.5 Breakdown of the Global Lyophilisation Market
3.5.1 Sales Forecast for cGMP Lyophilisers, 2011-2021
3.5.2 Sales Forecast for Laboratory Lyophilisers, 2011-2021
3.5.3 Sales Forecast for Lyophilisation Services, 2011-2021
3.6 Leading National Markets for Lyophilisation Technology and Services, 2010
3.6.1 Leading National Markets for Lyophilisation Technology and Services: Sales Forecast, 2011-2021
3.6.2 The US Lyophilisation Technology and Services Market, 2011-2021
3.6.3 The Japanese Lyophilisation Technology and Services Market, 2011-2021
3.6.4 The Leading European Lyophilisation Technology and Services Markets, 2011-2021
3.6.5 Emerging Economy Lyophilisation Technology and Services Markets
3.6.6 The Chinese Lyophilisation Technology and Services Market, 2011-2021
3.6.7 The Indian Lyophilisation Technology and Services Market, 2011-2021
4. Worldwide Market for Lyophilised Products and Technology
4.1 Therapeutic Areas Offering Growth Opportunities
4.2 Development of Biologics and Vaccines Will Drive the Lyophilisation Market, 2011-2021
4.3 The Leading Sectors of Biological Drugs Market in 2010
4.3.1 Monoclonal Antibodies Currently Lead the Biotech Market
4.3.1.1 Long-Term Prospects for Monoclonal Antibodies and Implications for the Lyophilisation Market
4.3.2 The Human Insulins Class Will Exhibit Strong Growth
4.3.3 Erythropoietin Products - How Will Reported Safety Affect Sales?
4.3.3.1 Erythropoietin Products Forecast, 2011-2021
4.3.4 The Interferons Class will Show an Increase in Revenues from 2010-2015
4.3.4.1 Long-Term Forecast for the Interferons Class
4.3.5 Granular-Colony Stimulating Factors (G-CSF), 2011-2021
4.3.6 Recombinant Coagulation Factors Will Show Steady Growth
4.3.7 Other Therapeutic Proteins
4.3.8 Biosimilars Market, 2010
4.3.8.1 Forecast for the Biosimilars Market, 2011-2021
4.3.9 Vaccines Market, 2010-2021
5. Systems, Consumables and Service Providers in the Lyophilisation Industry and Market
5.1 Products and Services in the Lyophilisation Market
5.1.1 Equipment Providers
5.1.2 Consumables Providers
5.1.3 Contract Manufacturing Organisations (CMOs) Providing Lyophilisation Services
5.2 Profiles of Some Leading Companies
5.2.1 GEA Lyophil
5.2.1.1 Overview
5.2.1.2 Capabilities of GEA Lyophil
5.2.1.3 GEA Lyophil's Research and Development Freeze Dryers
5.2.1.4 GEA Lyophil's Pilot Freeze Dryers
5.2.1.5 GEA's Lyovac Production Lyophilisers
5.2.1.6 Lyophilisation Production Systems
5.2.1.7 GEA's Retrofits of Lyophilisers
5.2.1.8 GEA's VAPOVAC: Technology for Freeze Dryer Sterilisation
5.2.1.9 ALUS: GEA Lyophil's Automatic Loading and Unloading Systems for Lyophilisers
5.2.1.10 GEA's Thermodynamic Lyophilisation Control
5.2.1.11 GEA Lyophil's Fast Track Project Management
5.2.2 Labconco Corporation
5.2.2.1 Overview
5.2.2.2 Global Presence
5.2.2.3 Product Focus
5.2.2.4 Dry Ice Benchtop Freeze Dry System
5.2.2.5 FreeZone Benchtop Freeze Dry Systems
5.2.2.6 FreeZone Console Freeze Dry Systems
5.2.2.7 FreeZone Plus Cascade Freeze Dry Systems
5.2.2.8 FreeZone Triad Freeze Dry Systems
5.2.2.9 Labconco Freeze Dry Accessories
5.2.2.10 R&D
5.2.2.11 Future Outlook
5.2.3 Vetter Pharma-Fertigung
5.2.3.1 An Overview
5.2.3.2 Global Presence
5.2.3.3 Business Interests
5.2.3.3.1 Vetter Development Service
5.2.3.3.2 Vetter Commercial Manufacturing
5.2.3.3.3 Vetter Solutions
5.2.3.4 Capabilities
5.2.3.5 R&D
5.2.3.6 Product Focus
5.2.3.6.1 Dual-Chamber Technology
5.2.3.7 Future Outlook
5.2.4 Piramal Pharma Solutions
5.2.4.1 Overview
5.2.4.2 Global Presence
5.2.4.3 Strengths and Capabilities
6. SWOT Analysis of the Lyophilisation Technology Market
6.1 Introduction
6.2 Commercial Drivers of the Lyophilisation Technology Market
6.3 Commercial Restraints for the Lyophilisation Technology Market
6.3.1 High Entry Barriers to Sector
6.3.2 Product Formulation Challenges
6.3.3 R&D Stage for Lyophilised Products
6.3.4 Scale-up Stage for Lyophilised Products
6.3.5 Main Issues at Large Scale Production Stage for Lyophilised Products
6.3.6 Main Challenges in a Freeze Drying Plant
6.3.7 Main Issues in Production
6.3.8 Typical Deficiencies in a Freeze Drying Process
6.4 Challenges Facing the Lyophilisation Technology Industry and Market
6.4.1 Spray Drying of Biopharmaceuticals
6.4.2 Other Methods in Development
6.4.2.1 Roche's Precipitation Method
7. Opinion from Our Survey of the Industry
7.1 Interview with Ms Jennifer Thompson, VP Corporate Development & Investor Relations, EnWave Corporation and Ms Florian Loesch, Sales Manager, Optima Pharma Group
7.1.1 Market for Lyophilised Products and Outsourcing of Lyophilisation Work
7.1.2 On the Key Unmet Needs and Driving Forces
7.1.3 Novel Dehydration Technologies in Development by EnWave Corporation
7.1.4 Development Status of bioREV and freezeREV Technology
7.1.5 On the Advantages Offered by bioREV and freezeREV
7.2 Authority from a Company in the Sector (Views Provided Anonymously)
7.2.1 Market for Lyophilised Products
7.2.2 Outsourcing of Lyophilisation Work
7.2.3 On the Key Unmet Needs and Driving Forces
7.2.4 On the Capability and Capacity of the CMO
7.3 Interview with Dr Steven Nail, Baxter Healthcare Corporation, USA
7.3.1 Market Valuation for Freeze Drying?
7.3.2 Products Suitable for Lyophilisation
7.3.3 Percentage of Lyophilised Products on Market
7.3.4 Key Areas for Research and Development
7.3.5 On Advantages of Lyophilisation
7.3.6 On Advantages of Lyophilisation over Other Drug Delivery Systems
7.3.7 On Drawbacks of Lyophilisation over Other Technologies
7.3.8 On Novel Technologies and Developments
8. Conclusions
8.1 Overview
8.2 Prominent Companies in the Market
8.3 Commercial Drivers of the Lyophilisation Market
8.4 Future Outlook and Concluding Remarks
List of Tables
Table 3.1 List of Some Lyophilised Orally Disintegrating Tablets, 2011
Table 3.2 World Lyophilisation Market by Leading Categories ($bn), 2010
Table 3.3 Lyophilisation Technology and Services: World Sales Forecast ($bn), 2010-2021
Table 3.4 Lyophilisation Technology and Services: World Sales Forecasts for Submarkets ($bn), 2010-2021
Table 3.5 cGMP Lyophilisers: World Sales Forecast ($bn), 2010-2021
Table 3.6 Laboratory Lyophilisers: World Sales Forecast ($bn), 2010-2021
Table 3.7 Lyophilisation Services Market: World Sales Forecast ($bn), 2010-2021
Table 3.8 Leading National Markets for Lyophilisation Technology and Services ($bn), 2010
Table 3.9 Leading Lyophilisation National Market Forecasts, 2010-2021
Table 3.10 Leading National Markets: Market Shares (%), 2010, 2015 & 2021
Table 4.1 Leading Product Classes Driving the Lyophilisation Market, 2010
Table 4.2 List of Some Currently Marketed Lyophilised Monoclonal Antibodies, 2011
Table 4.3 Monoclonal Antibodies Market: World Sales Forecast ($bn), 2010-2021
Table 4.4 Insulins Market: World Sales Forecast ($bn), 2010-2021
Table 4.5 Erythropoietins Market: World Sales Forecast ($bn), 2010-2021
Table 4.6 List of Some Currently Marketed Lyophilised Interferon Drugs, 2011
Table 4.7 Interferons Market: World Sales Forecast ($bn), 2010-2021
Table 4.8 G-CSF Market: World Sales Forecast ($bn), 2010-2021
Table 4.9 List of Some Currently Marketed Lyophilised Recombinant Coagulation Factors, 2011
Table 4.10 Recombinant Coagulations Factors Market: World Sales Forecast ($bn), 2010-2021
Table 4.11 List of Some Currently Marketed Lyophilised Human Growth Hormones, 2011
Table 4.12 List of Some Currently Marketed Lyophilised Immunosuppressants, 2011
Table 4.13 Other Therapeutic Proteins Market: World Sales Forecast ($bn), 2010-2021
Table 4.14 List of Some Currently Marketed Lyophilised Biosimilar Drugs, 2011
Table 4.15 Biosimilars Market: World Sales Forecast ($bn), 2010-2021
Table 4.16 List of Some Currently Marketed Lyophilised Vaccines, 2011
Table 4.17 Total Vaccines Market: World Sales Forecast ($bn), 2010-2021
Table 5.1 Companies that Provide Freeze Dryers and Associated Systems to the Pharmaceutical Industry, 2011
Table 5.2 Companies Providing Vials Suitable for Lyophilisation, 2011
Table 5.3 CMOs Providing Lyophilisation Services, 2011
Table 5.4 GEA Pharma Systems: A Historical Perspective
Table 5.5 Labconco Corporation: A Brief History
Table 6.1 SWOT Analysis of the Lyophilisation Industry and Market, 2011-2021
Table 6.2 Comparison between Lyophilisation and Spray Drying, 2011
Table 6.3 Advantages of a Spray Dryer for Drying Applications, 2011
Table 8.1 Lyophilisation Market: World Sales Forecasts, 2010, 2012, 2015, 2018 and 2021
List of Figures
Figure 2.1 The Primary Steps in Freeze Drying
Figure 2.2 Typical Lyophilisation (Freeze Drying) Process
Figure 2.3 Components of a Typical Freeze Dryer
Figure 3.1 World Lyophilisation Market Shares (%) by Leading Categories, 2010
Figure 3.2 Lyophilisation Technology and Services: World Sales Forecast ($bn), 2010-2021
Figure 3.3 Lyophilisation Market: World Sales Forecast ($bn), 2010-2021
Figure 3.4 cGMP Lyophilisers: World Sales Forecast ($bn), 2010-2021
Figure 3.5 Laboratory Lyophilisers: World Sales Forecast ($bn), 2010-2021
Figure 3.6 Lyophilisation Services Market: World Sales Forecast ($bn), 2010-2021
Figure 3.7 Lyophilisation Sales Shares (%) in Leading National Markets, 2010
Figure 3.8 Lyophilisation Sales Shares (%) in Leading National Markets, 2015
Figure 3.9 Lyophilisation Sales Shares (%) in Leading National Markets, 2021
Figure 3.10 The US Lyophilisation Technology and Services Market Forecast ($bn), 2010-2021
Figure 3.11 The Japanese Lyophilisation Technology and Services Market Forecast ($bn), 2010-2021
Figure 3.12 Leading European Lyophilisation Technology and Services Markets: Forecasts ($bn), 2010-2021
Figure 3.13 The Chinese and Indian Lyophilisation Technology and Services Markets: Forecasts ($bn), 2010-2021
Figure 4.1 Monoclonal Antibodies Market: World Sales Forecast ($bn), 2010-2021
Figure 4.2 Insulins Market: World Sales Forecast ($bn), 2010-2021
Figure 4.3 Erythropoietins Market: World Sales Forecast ($bn), 2010-2021
Figure 4.4 Interferons Market: World Sales Forecast ($bn), 2010-2021
Figure 4.5 G-CSF Market: World Sales Forecast ($bn), 2010-2021
Figure 4.6 Recombinant Coagulation Factors Market: World Sales Forecast ($bn), 2010-2021
Figure 4.7 Other Therapeutic Proteins Market: World Sales Forecast ($bn), 2010-2021
Figure 4.8 Biosimilars Market: World Sales Forecast ($bn), 2010-2021
Figure 4.9 Total Vaccines Market: World Sales Forecast ($bn), 2010-2021
Figure 8.1 Lyophilisation Market: World Sales Forecast, 2010, 2012, 2015, 2018 and 2021