1. Executive Summary
1.1 Aims, Scope and Format of the Report
1.2 Research Methods
2. Ophthalmic Disorders and Treatments
2.1 The Ophthalmology Market
2.2 Ophthalmic Disorders
2.3 The Human Eye and the Vision Process
2.4 Glaucoma
2.4.1 Primary Open Angle Glaucoma: The Most Common Type of Glaucoma
2.4.2 Closed Angle Glaucoma
2.4.3 Secondary Glaucoma
2.4.4 Congenital Glaucoma
2.4.5 Normal Tension Glaucoma
2.4.6 Ocular Hypertension
2.4.7 Glaucoma Risk Factors
2.4.8 Diagnosis of Glaucoma
2.4.9 Prevalence of Glaucoma
2.4.10 Treatment of Glaucoma
2.4.11 Prostaglandins are the First-Line Treatment of Choice
2.4.12 Second-Line Glaucoma Treatments
2.4.13 Combination Treatments
2.4.14 Laser Treatment
2.4.15 Surgery (Trabeculectomy)
2.5 Age-Related Macular Degeneration (AMD)
2.5.1 Dry AMD
2.5.2 Wet AMD
2.5.3 AMD Risk Factors
2.5.4 Diagnosis of AMD
2.5.5 Prevalence of AMD
2.5.6 Treatment of AMD
2.6 Diabetic Retinopathy
2.6.1 Diagnosis of Diabetic Retinopathy
2.6.2 Prevalence of Diabetic Retinopathy
2.6.3 Laser and Surgical Treatments are the Main Treatments for Diabetic Retinopathy
2.6.4 Pharmaceutical Treatments
2.7 Ophthalmic Allergies
2.7.1 Allergic Conjunctivitis is the Most-Common Eye Allergy
2.7.2 Ophthalmic Allergy Treatments
2.8 Ophthalmic Inflammatory Disorders
2.8.1 Uveitis is the Most Common Ocular Inflammatory Disease
2.8.2 Ophthalmic Inflammatory Drugs
2.9 Ophthalmic Infections
2.9.1 Types of Eye Infection
2.9.2 Treatment of Eye Infections
2.10 Dry Eye Syndrome
2.10.1 Causes and Prevalence of Dry Eye Syndrome
2.10.2 The Mainstay of Dry Eye Treatment is Artificial Tears
2.10.3 Prescription-Only Drugs for Dry Eye are Limited
2.10.4 Tear Augmenters (Punctal Plugs)
3. The Global Ophthalmic Pharmaceutical Market 2010-2025
3.1 The Ophthalmic Pharmaceutical Market in 2009
3.1.1 Anti-Glaucoma had the Largest Market Share in 2009
3.1.2 Top Twenty Ophthalmic Pharmaceutical Brands, 2009
3.1.3 Three Manufacturers Account for Almost Half the Market
3.2 Global Ophthalmic Pharmaceutical Market Forecasts, 2010-2025
3.2.1 Generic Competition in the Ophthalmic Pharmaceutical Market from 2010-2016
3.2.2 What are the Prospects for the Ophthalmic Pharmaceutical Market from 2016-2025?
3.3 Ophthalmic Pharmaceutical Therapeutic Category Market Forecasts, 2010-2025
3.3.1 Retinal Disorders Will Power Growth from 2010-2016
3.3.2 Retinal Disorder Drug Growth Will Continue Through 2016-2020
3.3.3 High Growth and Return to Market-Leading Position for Anti-Glaucoma Drugs from 2020-2025?
4. The Anti-Glaucoma Market 2010-2025
4.1 The Anti-Glaucoma Market in 2009
4.1.1 Prostaglandin Analogues Led the Anti-Glaucoma Market in 2009
4.1.2 Xalatan
4.1.3 Travatan
4.1.4 Cosopt
4.1.5 Lumigan
4.1.6 Alphagan
4.1.7 Azopt
4.1.8 Xalacom
4.1.9 Trusopt
4.1.10 Combigan
4.2 Anti-Glaucoma Market Forecasts, 2010-2025
4.2.1 Generic Competition Will Impact Upon the Anti-Glaucoma Market from 2010-2016
4.2.2 Novel Anti-Glaucoma Drugs Will Drive Growth from 2010-2025
4.2.3 Xalatan Sales Forecast, 2010-2025
4.2.4 Travatan Sales Forecast, 2010-2025
4.2.5 Cosopt Sales Forecast, 2010-2025
4.2.6 Lumigan Sales Forecast, 2010-2025
4.2.7 Alphagan Sales Forecast, 2010-2025
4.2.8 Azopt Sales Forecast, 2010-2025
4.2.9 Xalacom Sales Forecast, 2010-2025
4.2.10 Trusopt Sales Forecast, 2010-2025
4.2.11 Combigan Sales Forecast, 2010-2025
5. The Ophthalmic Anti-Allergy/Inflammatory/Infective Market 2010-2025
5.1 The Ophthalmic Anti-Allergy/Inflammatory/Infective Market in 2009
5.1.1 Patanol
5.1.2 Vigamox/Vegamox
5.1.3 TobraDex
5.1.4 Pataday
5.1.5 Acular
5.1.6 Cravit
5.1.7 Zymar
5.2 Ophthalmic Anti-Allergy/Inflammatory/Infective Market Forecasts, 2010-2025
5.2.1 Innovation in the Anti-Allergy/Inflammatory/Infective R&D Pipeline
5.2.2 Patanol Sales Forecast, 2010-2025
5.2.3 Vigamox Sales Forecast, 2010-2025
5.2.4 TobraDex Sales Forecast, 2010-2025
5.2.5 Pataday Sales Forecast, 2010-2025
5.2.6 Acular Sales Forecast, 2010-2025
5.2.7 Cravit Sales Forecast, 2010-2025
5.2.8 Zymar Sales Forecast, 2010-2025
6. The Retinal Disorder Market 2010-2025
6.1 The Retinal Disorder Market in 2009
6.1.1 Wet AMD has the Largest Market Share of the Retinal Disorder Market
6.1.2 Lucentis Took Control of the Retinal Disorder Market in 2009
6.1.3 Visudyne was the Second-Highest-Selling Retinal Disorder Drug in 2009
6.1.4 Lucentis has Sidelined Macugen but Faces Potent Threat from Avastin
6.2 Retinal Disorder Market Forecasts, 2010-2025
6.2.1 Lucentis Will Drive the Retinal Disorder Market from 2010-2016
6.2.2 Novel Drugs and New Disease Treatments will Drive Growth from 2016-2025
6.2.3 Lucentis Sales Forecast, 2010-2025
6.2.4 Visudyne Sales Forecast, 2010-2025
7. The Dry Eye Market 2010-2025
7.1 The Dry Eye Market in 2009
7.1.1 Restasis is the Only Prescription Drug for Dry Eye in the US
7.1.2 Hyalein: Marketed in Japan and China
7.1.3 Allergan’s Celluvisc is the Third-Best-Selling Dry Eye Brand
7.1.4 The OTC Market for Artificial Tears is Fragmented and Competitive
7.2 Dry Eye Market Forecasts, 2010-2025
7.2.1 Increased Sales of Dry Eye Prescription Drugs Predicted from 2009-2013
7.2.2 Growth in the Dry Eye Market Will Moderate After 2013
7.2.3 Restasis Sales Forecast, 2010-2025
7.2.4 Hyalein Sales Forecast, 2010-2025
7.2.5 Celluvisc Sales Forecast, 2010-2025
8. Issues Affecting the Market for Ophthalmic Pharmaceuticals
8.1 SWOT Analysis of the Ophthalmic Pharmaceutical Market
8.2 Strengths of the Ophthalmic Pharmaceutical Market
8.2.1 Development of New Drug Delivery Methods and Formulations
8.2.2 Intraocular Injections
8.2.3 Sustained-Release Ocular Implants
8.2.4 Gene Therapy and RNA Interference Technology
8.2.5 New Ophthalmic Therapeutic Applications for Drugs
8.2.6 Development of Neuroprotective Anti-Glaucoma Medications
8.3 Weaknesses of the Ophthalmic Pharmaceutical Market
8.3.1 The Ophthalmic Pharmaceutical Market Will Face Generic Competition
8.3.2 Avastin Cannibalising Lucentis' Revenues?
8.4 Opportunities for the Ophthalmic Pharmaceutical Market
8.4.1 The Greying of the World Population
8.4.2 Increasing Prevalence of Diabetes and Unhealthy Lifestyles
8.4.3 Increasing Prevalence of Eye Disorders
8.4.4 Retinal Disorders Will Have the Most-Marked Increases in Prevalence
8.4.5 Increasing Prevalence of Glaucoma, Dry Eye and Other Ophthalmic Disorders
8.4.6 Generous Reimbursement for Ophthalmic Pharmaceuticals
8.5 Threats Facing the Ophthalmic Pharmaceutical Market
8.5.1 Poor Patient Compliance
8.5.2 The Rate of Diagnosis for Many Eye Disorders is Low
9. Ophthalmic Pharmaceutical Country Markets 2010-2025
9.1 Leading Ophthalmic Pharmaceutical Country Markets, 2009
9.2 Leading Developed Country Ophthalmic Pharmaceutical Markets, 2010-2025
9.2.1 The US Ophthalmic Pharmaceutical Market, 2010-2025
9.2.2 The Japanese Ophthalmic Pharmaceutical Market, 2010-2025
9.2.3 European Ophthalmic Pharmaceutical Markets, 2010-2025
9.3 Emerging Economy Ophthalmic Pharmaceutical Market Forecasts, 2010-2025
9.3.1 Ophthalmic Pharmaceuticals are Making the Leap to Developing Countries
9.3.2 The Chinese Ophthalmic Pharmaceutical Market, 2010-2025
9.3.3 The Indian Ophthalmic Pharmaceutical Market, 2010-2025
10. The Ophthalmic Pharmaceutical R&D Pipeline
10.1 The Ophthalmic Pharmaceutical Pipeline: Richest in Anti-Glaucoma and Retinal Disorder Drugs
10.2 The Anti-Glaucoma Pipeline
10.2.1 Neuroprotection Will Be the Most Important Anti-Glaucoma Pipeline Development
10.2.2 Taflotan/DE-085 (Santen/Asahi)
10.2.3 Azarga (Alcon)
10.2.4 Anecortave (Alcon)
10.2.5 DNB-001 (Danube)
10.2.6 BVT.28949 (Biovitrum)
10.2.7 OT-730 (Othera)
10.2.8 AL-37807 (Alcon)
10.2.9 PF-4217329 (Pfizer)
10.2.10 QLT's Punctal Plug Delivery Technology
10.2.11 PF-03187207 (NicOx/Pfizer)
10.3 The Ophthalmic Anti-Allergy Pipeline
10.3.1 Bepreve (ISTA/Senju)
10.3.2 FOV1101 (Fovea/CombinatoRx)
10.3.3 DE-103 (Santen)
10.4 The Ophthalmic Anti-Inflammatory Pipeline
10.4.1 T-Pred (ISTA)
10.4.2 AzaSite Plus/ASV-502 (InSite Vision)
10.4.3 Durezol (Senju/Sirion Therapeutics)
10.4.4 Luveniq (Lux Biosciences)
10.4.5 Simulect (Cerimon)
10.4.6 EGP-437 (EyeGate Pharm)
10.5 The Ophthalmic Anti-Infective Pipeline
10.5.1 TobraDex ST (Alcon)
10.5.2 ISV-403/Besifloxacin (Bausch & Lomb)
10.5.3 Moxifloxacin/Dexamethasone (Alcon)
10.5.4 Aganocide (Alcon/NovaBay)
10.6 The Retinal Disease Pipeline
10.6.1 Retinal Diseases Have the Richest Pipeline
10.6.2 Arxxant (Eli Lilly/Alcon/Takeda)
10.6.3 Vitrase/Vitragen (ISTA)
10.6.4 Aflibercept/VEGF Trap-Eye (Regeneron/Bayer)
10.6.5 Bevasiranib/Cand5 (Opko)
10.6.6 Atacand/TCV-116 (AstraZeneca/Takeda)
10.6.7 Medidur (pSivida/Alimera Sciences/Pfizer)
10.6.8 NT-501 (Neurotech)
10.6.9 Microplasmin (ThromboGenics)
10.6.10 Sustained-Release Brimonidine (Allergan)
10.6.11 RTP801i-14/PF-4523655 (Quark/Pfizer)
10.6.12 AGN-745/SIRNA-027 (Allergan/Merck & Co.)
10.6.13 ATG-3 (CoMentis)
10.6.14 OT-551 (Othera)
10.6.15 Fenretinide (Sirion Therapeutics)
10.6.16 RPE65 Gene Therapy (Targeted Genetics)
10.7 The Dry Eye Pipeline
10.7.1 Prolacria (Inspire/Allergan/Santen)
10.7.2 Cyclosporine Ophthalmic Solution (Sirion Therapeutics)
10.7.3 Rebamipide (Otsuka/Acucela)
10.7.4 DE-101/Rivoglitazone (Santen)
10.7.5 Ecabet (ISTA)
10.7.6 SAR 1118 (SARcode)
10.8 The Pipeline for Other Ophthalmic Indications Includes Eyelash Growth Stimulators
11. Expert Views from Key Opinion Leaders
11.1 Barrett Katz, MD, MBA, Chief Executive Officer and Chief Medical Officer and Brian Levy, O.D., MSc, Chief Operating Officer, Danube Pharmaceuticals Inc., New York, USA
11.1.1 Neuroprotection is the Key Unmet Need Among Glaucoma Patients
11.1.2 Danube's Pipeline Anti-Glaucoma Medication: DNB-001
11.1.3 Key Threats Facing the Ophthalmic Pharmaceutical Industry
11.1.4 Major Growth Opportunities in the Ophthalmic Pharmaceutical Industry
11.1.5 The Future of the Anti-Glaucoma Market
11.2 Dr Al Reaves, PhD, Senior Vice President of Clinical Development, Othera Pharmaceuticals Inc., Conshohocken, PA, USA
11.2.1 Which Areas of the Ophthalmic Pharmaceutical Market will Experience Greatest Growth?
11.2.2 Othera's Geographic Atrophy Drug: OT-551
11.2.3 How Will Glaucoma be Treated in 2025?
11.2.4 Othera's Neuroprotective Anti-Glaucoma Drug: OT-440
11.2.5 Othera's New Generation Beta Blocker: OT-730
11.2.6 New Drugs for Ophthalmic Conditions Currently with No Treatments
11.3 Dr Victor Chong, MD, FRCS, FRCOphth, Consultant Ophthalmic Surgeon and Clinical Senior Lecturer in Ophthalmology, University of Oxford, Oxford Eye Hospital, England, UK
11.3.1 Key Unmet Needs
11.3.2 Research and Development
11.3.3 Problems with the Current Use of Ophthalmic Treatments
11.3.4 Challenges in the Development of Ophthalmic Drugs
11.3.5 Complexities Involved in Developing New Ophthalmic Drugs
11.3.6 Growth Opportunities in the Ophthalmic Market
11.3.7 Challenges Facing the Ophthalmic Pharma Industry
11.3.8 Main Regions Offering Growth Potential Worldwide
11.3.9 Needs of Glaucoma Patients
11.3.10 Future Treatments for Glaucoma
11.3.11 Pipeline Developments from a Physician's Perspective
11.3.12 Prospects for Replacing Current Treatments
11.3.13 Novel Treatments for Ophthalmic Diseases
12. Conclusions
12.1 The Ophthalmic Pharmaceutical Market in 2009
12.2 Visiongain's Ophthalmic Pharmaceutical Market Forecast, 2010-2025
12.3 Who Will Succeed in the Ophthalmic Pharmaceutical Market?
12.4 Where Will the Ophthalmic Pharmaceutical Market Grow Fastest?
Lists of Tables
Table 2.1 Glaucoma Drug Types, 2009
Table 2.2 AMD Drug Types, 2009
Table 2.3 Ophthalmic Allergy Drug Types, 2009
Table 2.4 Ophthalmic Inflammatory Disorder Drug Types, 2009
Table 2.5 Ophthalmic Anti-Infective Drug Types, 2009
Table 3.1 Ophthalmic Pharmaceutical Therapeutic Category Market Shares, 2009
Table 3.2 Top Twenty Ophthalmic Pharmaceutical Brands, 2009
Table 3.3 Top Ten Ophthalmic Pharmaceutical Manufacturers, 2009
Table 3.4 World Ophthalmic Pharmaceutical Market Sales Forecast, 2010-2016
Table 3.5 World Ophthalmic Pharmaceutical Market Sales Forecast, 2017-2025
Table 3.6 Ophthalmic Pharmaceutical Therapeutic Category Forecasts, 2010-2016
Table 3.7 Ophthalmic Pharmaceutical Therapeutic Category Forecasts, 2017-2025
Table 4.1 Leading Anti-Glaucoma Brands, 2009
Table 4.2 World Anti-Glaucoma Market Sales Forecast, 2010-2016
Table 4.3 World Anti-Glaucoma Market Sales Forecast, 2017-2025
Table 4.4 Leading Anti-Glaucoma Brands Sales Forecasts, 2010-2016
Table 4.5 Leading Anti-Glaucoma Brands Sales Forecasts, 2017-2025
Table 5.1 Therapeutic Category Market Shares in the Ophthalmic Anti- Allergy/Inflammatory/Infective Market, 2009
Table 5.2 Leading Anti-Allergy/Inflammatory/Infective Brands, 2009
Table 5.3 Ophthalmic Anti-Allergy/Inflammatory/Infective Market Sales Forecast, 2010-2016
Table 5.4 Ophthalmic Anti-Allergy/Inflammatory/Infective Market Sales Forecast, 2017-2025
Table 5.5 Leading Anti-Allergy/Inflammatory/Infective Brand Sales Forecasts, 2010-2016
Table 5.6 Leading Anti-Allergy/Inflammatory/Infective Brand Sales Forecasts, 2017-2025
Table 6.1 Therapeutic Category Market Shares in the Retinal Disorder Market, 2009
Table 6.2 Leading Retinal Disorder Brands, 2009
Table 6.3 World Retinal Disorder Market Sales Forecast, 2010-2016
Table 6.4 World Retinal Disorder Market Sales Forecast, 2017-2025
Table 6.5 Leading Retinal Disorder Brands Sales Forecast, 2010-2016
Table 6.6 Leading Retinal Disorder Brands Sales Forecast, 2017-2025
Table 7.1 Leading Dry Eye Brands, 2009
Table 7.2 World Dry Eye Market Sales Forecast, 2010-2016
Table 7.3 World Dry Eye Market Sales Forecast, 2017-2025
Table 7.4 Restasis Sales Forecast, 2010-2016
Table 7.5 Restasis Sales Forecast, 2017-2025
Table 7.6 Hyalein Sales Forecast, 2010-2016
Table 7.7 Hyalein Sales Forecast, 2017-2025
Table 7.8 Celluvisc Sales Forecast, 2010-2016
Table 7.9 Celluvisc Sales Forecast, 2017-2025
Table 8.1 SWOT Analysis of the Ophthalmic Pharmaceutical Market, 2010-2025
Table 8.2 Expected Patent Expiries for Leading Ophthalmic Pharmaceuticals, 2009-2014
Table 8.3 Global Ophthalmic Disorder Prevalence Forecast, 2007-2030
Table 9.1 Leading Ophthalmic Pharmaceutical Country Markets, 2009
Table 9.2 Leading Ophthalmic Pharmaceutical Country Market Sales Forecasts, 2010-2016
Table 9.3 Leading Ophthalmic Pharmaceutical Country Market Sales Forecasts, 2017-2025
Table 10.1 Key Drugs in the Anti-Glaucoma Pipeline, 2009
Table 10.2 Key Drugs in the Ophthalmic Anti-Allergy Pipeline, 2009
Table 10.3 Key Drugs in the Ophthalmic Anti-Inflammatory Pipeline, 2009
Table 10.4 Key Drugs in the Ophthalmic Anti-Infective Pipeline, 2009
Table 10.5 Key Drugs in the Retinal Disease Pipeline, 2009
Table 10.6 Key Drugs in the Dry Eye Pipeline, 2009
Table 10.7 Key R&D Pipeline Drugs for Other Ophthalmic Indications, 2009
Lists of Figures
Figure 3.1 Ophthalmic Pharmaceutical Therapeutic Category Market Shares, 2009
Figure 3.2 Top Ten Ophthalmic Pharmaceutical Manufacturers, 2009
Figure 3.3 World Ophthalmic Pharmaceutical Market Sales Forecast, 2010-2025
Figure 3.4 Ophthalmic Pharmaceutical Therapeutic Category Market Shares and Sales Forecasts, 2010-2025
Figure 3.5 Ophthalmic Pharmaceutical Therapeutic Category Sales Forecasts, 2010-2025
Figure 4.1 Leading Anti-Glaucoma Brands, 2009
Figure 4.2 World Anti-Glaucoma Market Sales Forecast, 2010-2025
Figure 4.3 Leading Anti-Glaucoma Brands, 2016
Figure 4.4 Xalatan Sales Forecast, 2010-2025
Figure 4.5 Travatan Sales Forecast, 2010-2025
Figure 4.6 Cosopt Sales Forecast, 2010-2025
Figure 4.7 Lumigan Sales Forecast, 2010-2025
Figure 4.8 Alphagan Sales Forecast, 2010-2025
Figure 4.9 Azopt Sales Forecast, 2010-2025
Figure 4.10 Xalacom Sales Forecast, 2010-2025
Figure 4.11 Trusopt Sales Forecast, 2010-2025
Figure 4.12 Combigan Sales Forecast, 2010-2025
Figure 5.1 Therapeutic Category Market Shares in the Ophthalmic Anti- Allergy/Inflammatory/Infective Market, 2009
Figure 5.2 Ophthalmic Anti-Allergy/Inflammatory/Infective Market Sales Forecast, 2010-2025
Figure 5.3 Patanol Sales Forecast, 2010-2025
Figure 5.4 Vigamox Sales Forecast, 2010-2025
Figure 5.5 TobraDex Sales Forecast, 2010-2025
Figure 5.6 Pataday Sales Forecast, 2010-2025
Figure 5.7 Acular Sales Forecast, 2010-2025
Figure 5.8 Cravit Sales Forecast, 2010-2025
Figure 5.9 Zymar Sales Forecast, 2010-2025
Figure 6.1 Therapeutic Category Market Shares in the Retinal Disorder Market, 2009
Figure 6.2 Leading Retinal Disorder Brands, 2009
Figure 6.3 World Retinal Disorder Market Sales Forecast, 2010-2025
Figure 6.4 Lucentis Sales Forecast, 2010-2025
Figure 6.5 Visudyne Sales Forecast, 2010-2025
Figure 7.1 World Dry Eye Market Sales Forecast, 2010-2025
Figure 7.2 Restasis Sales Forecast, 2010-2025
Figure 7.3 Hyalein Sales Forecast, 2010-2025
Figure 7.4 Celluvisc Sales Forecast, 2010-2025
Figure 8.1 Global Population Aged Over 65, 2010-2025
Figure 8.2 Population Aged 65 Years or Over in Major Ophthalmic Pharmaceutical Country Markets, 2009 and 2025
Figure 8.3 Global Prevalence of Diabetes and Diabetic Retinopathy, 2007 and 2030
Figure 9.1 Leading Ophthalmic Pharmaceutical Country Markets, 2009
Figure 9.2 Leading Ophthalmic Pharmaceutical Country Markets, 2015
Figure 9.3 Leading Ophthalmic Pharmaceutical Country Markets, 2020
Figure 9.4 Leading Ophthalmic Pharmaceutical Country Markets, 2025
Figure 9.5 US and Japanese Ophthalmic Pharmaceutical Market Sales Forecasts, 2010-2025
Figure 9.6 European, Brazilian, Indian and Chinese Ophthalmic Pharmaceutical Market Sales Forecasts, 2010-2025
Figure 12.1 World Ophthalmic Pharmaceutical Market Sales Forecast, 2010-2025