1 Executive Summary: Sleep Disorders Market Analysis 2009-2024
2 An Introduction to Sleep Disorders
2.1 Sleep Hygiene
2.2 Measuring Sleep
2.3 Circadian Rhythm
2.4 Sleep Disorders
2.4.1 Dyssomnias
2.4.2 Parasomnias
2.5 The Treatment of Sleep Disorders
2.5.1 Therapeutic Approaches
2.5.2 Medical Therapies
2.5.3 Alternative Therapies
2.5.4 OTC Products
2.6 Pharmacological Treatments
2.6.1 Specific Treatments
2.6.2 Off-Label Treatments
3 The Global Sleep Disorder Market Forecast
3.1 The World Market
3.1.1 Growth in the World Sleep Disorder Market to 2012
3.1.2 Growth in the World Sleep Disorder Market from 2013
3.2 The Global Sleep Disorder Market Geographical Breakdown
3.2.1 Sleep Disorder Market Forecast - US
3.2.2 Sleep Disorder Market Forecast - Japan
3.2.3 Sleep Disorder Market Forecast – European Markets
3.2.4 Sleep Disorder Market Forecast – Emerging Markets
4 Insomnia Market Analysis and Forecasts
4.1 The Total Insomnia Market Forecast
4.1.1 Increased Use and Access to Insomnia Treatments Will Drive Market Growth
4.1.2 Pipeline Treatments Will Revive the Insomnia Market
4.2 Ambien Forecast 2009-2024
4.2.1 How Will Generic Competition Impact Upon Ambien Sales?
4.2.2 Will Pipeline Products Make Ambien Treatment Obsolete?
4.3 Lunesta Forecast 2009-2024
4.3.1 Lunesta Will Experience Revenue Growth in the Early Forecast Years
4.3.2 Patent Expiry in 2012 – What Effects?
4.4 Lendormin Forecast 2009-2024
4.4.1 Lendormin Revenues Over the Forecast Period
4.5 Imovane Forecast 2009-2024
4.5.1 How Will Generics and Novel Compounds Affect Imovane Revenues?
4.6 Rozerem Forecast 2009-2024
4.6.1 Will Generic Eszopiclone Seriously Affect Rozerem Sales?
4.6.2 Generic Ramelteon and New Long-Term Treatment Options
4.7 Total Other Insomnia Drugs Market Forecast 2009-2024
4.7.1 Generic Zolpidem – What Effects on Market?
4.7.2 New Pipeline Agents and the Market Entry of More Generic Agents
4.7.3 Generic Ambien CR and Pipeline Products
4.8 Insomnia Market Summary
5 Restless Leg Syndrome Market Analysis and Forecasts
5.1 The Total RLS Market Forecast 2009-2024
5.2 Mirapex Forecast 2009-2024
5.2.1 Patent Expiries and Generic Competition
5.3 Requip Forecast 2009-2024
5.3.1 Competition from Generics and Pipeline Products
5.4 Total Other RLS Drugs Forecast 2009-2024
5.5 RLS Market Forecast Summary
6 Wake-Promoting Drugs Market Analysis and Forecasts
6.1 The Total Wake-Promoting Market Forecast 2009-2024
6.2 Provigil Forecast 2009-2024
6.2.1 How Will Sales of Provigil be Affected by Market Entry of Nuvigil?
6.2.2 Loss of Marketing Exclusivity from 2015
6.2.3 How Competition with Pipeline Agents Will Affect Growth to 2024
6.3 Nuvigil Forecast 2010-2024
6.3.1 Nuvigil Will Experience Consistent Growth from a Large Treatment Base
6.3.2 Growth of Nuvigil Will Slow Due to Entry of New Agents
6.4 Xyrem Forecast 2009-2024
6.4.1 Xyrem Will See Increased Revenues in the Early Forecast Years
6.4.2 New Agents Will Result in Negative Growth in the Later Forecast Years
6.5 Other Wake-Promoting Drugs: Forecast 2009-2024
7 Sleep Disorder Treatments: SWOT Analysis, 2009-2024
7.1 Market Drivers
7.2 Market Restraints
7.3 Current Treatments
7.4 The Large, Competitive Market
7.5 New Insomnia Drugs Will Drive Market Growth
7.6 High Sleep Disorder Prevalence and Unmet Market Needs
7.7 Public Opinion
7.8 Sleep Apnea Market Drivers and Restraints
8 The Sleep Disorder Treatment Pipeline
8.1 Insomnia Treatment Pipeline
8.1.1 Zolpimist (Novadel)
8.1.2 Edluar (Meda)
8.1.3 Silenor (Somaxon)
8.1.4 Indiplon (Neurocrine Biosciences)
8.1.5 Ciltyri (Sanofi-Aventis)
8.1.6 Intermezzo (Transcept)
8.1.7 Almorexant (GSK/Actelion)
8.1.8 Tasimelteon (Vanda)
8.1.9 Medodorm (Essential Nutrition)
8.1.10 Esmirtazapine (Schering-Plough)
8.1.11 Gabitril (Cephalon)
8.1.12 649868 (GSK)
8.1.13 EVT 201 (Evotec)
8.1.14 PD 200390 (Pfizer)
8.1.15 TIK 301 (Tikvah Therapeutics)
8.1.16 HY 10275 (Hypnion)
8.1.17 LY 2624803 (Eli Lilly)
8.1.18 Pruvanserin (Eli Lilly)
8.1.19 MK 4305 (Merck & Co)
8.1.20 TGARO1H (Fabre Kramer)
8.1.21 ITI 007 (Intra-Cellular Therapies)
8.1.22 Staccato Zaleplon (Alexza)
8.1.23 SKP 1041 (Somnus)
8.1.24 Pimavanserin (Acadia)
8.1.25 NBI 75043 (Neurocrine Biosciences)
8.1.26 Adipiplon (Neurogen)
8.1.27 Summary of Promising Late-Stage Insomnia Pipeline Products
8.2 Wake-Promoting Sleep Disorder Treatment Pipeline
8.2.1 Nuvigil (Cephalon)
8.2.2 Tiprolisant (Bioprojet)
8.2.3 CX 717 (Cortex)
8.2.4 VSF 173 (Vanda)
8.2.5 APD 916 (Arena)
8.2.6 COL 204 (CoLucid)
8.2.7 Concluding Thoughts on the Wake-Promoting Pipeline
8.3 Restless Legs Syndrome Treatment Pipeline
8.3.1 NEUPRO (UCB Pharma)
8.3.2 NENAD (Axxonis Pharma AG)
8.3.3 Solzira (Xenoport)
8.3.4 Aplindore (Neurogen)
8.3.5 JZP 7 (Jazz Pharmaceuticals)
8.3.6 Istradefylline (Kyowa Hakko Kirin)
8.3.7 Safinamide (Merck Serono)
8.3.8 Nitisinone (Synosia Therapeutics)
8.3.9 Concluding Notes on the RLS Pipeline
8.4 Sleep Apnea Pharmaceutical Treatment Pipeline
8.4.1 BGC20 0166 (BTG and Collegium)
8.4.2 AVE 0657 (Sanofi-Aventis)
8.4.3 CX 1739 (Cortex)
8.4.4 Gall 200 (Galleon)
8.4.5 Factors Affecting Sleep Apnea Pharmaceutical Market Potential
9 An Expert's Opinion – Dr. Remy Luthringer
9.1 Unmet Needs in the Treatment of Sleep Disorders
9.2 The Future of the Wake-Promoting Market
9.3 The Insomnia Market
9.4 Long-Term and Off-Label Use of Insomnia Treatments
9.5 The Sleep Disorder Pipeline
9.6 The Evolution of Sleep Disorder Treatments
9.7 Growth in the Sleep Disorder Market
10 Conclusions
10.1 Sleep Disorders Constitute a Large Market Opportunity
10.2 The World Market for Sleep Disorder Treatments Will Grow Over the Forecast Period
10.3 The Global Market Distribution Will Change over the Forecast Period
10.4 The Insomnia Treatment Market
10.5 Restless Leg Syndrome Treatment Market
10.6 The Wake-Promoting Drug Market
10.7 Drivers and Restraints
10.8 The Sleep Disorder Treatment Pipeline Overview
10.8.1 Insomnia Pipeline
10.8.2 Wake-Promoting Pipeline
10.8.3 Restless Legs Syndrome Pipeline
10.8.4 Sleep Apnea Pipeline
List of Tables
Table 2.1 Dyssomnia Sleep Disorders
Table 2.2 Parasomnia Sleep Disorders
Table 3.1 Global Sleep Disorder Market Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 3.2 Sleep Disorder Comparative Forecast Sales ($m), 2009-2024
Table 3.3 Sleep Disorder Comparative Forecast by Market Share (%), 2009-2024
Table 3.4 Geographical Market Share (%) Forecast to 2024
Table 3.5 Geographical Sales ($m) Forecast to 2024
Table 4.1 Total Insomnia Market Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.2 Ambien Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.3 Lunesta Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.4 Lendormin Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.5 Imovane Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.6 Rozerem Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.7 Total Other Insomnia Drugs Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 4.8 Insomnia Drug Market Share (%) Comparative Forecast, 2009-2024
Table 5.1 Total RLS Market Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 5.2 Mirapex Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 5.3 Requip Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 5.4 Total Other RLS Drugs Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 5.5 RLS Drug Market Share (%) Comparative Forecast, 2009-2024
Table 6.1 Total Wake-Promoting Market Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 6.2 Provigil Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 6.3 Nuvigil Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 6.4 Xyrem Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 6.5 Total Other Wake-Promoting Drugs Forecast Sales ($m), Growth (%) and CAGR (%), 2009-2024
Table 7.1 A SWOT Analysis of the Sleep Disorder Market, 2009-2024
Table 8.1 The Insomnia Treatment Pipeline, 2009
Table 8.2 The Wake-Promoting Sleep Disorder Treatment Pipeline, 2009
Table 8.3 The RLS Treatment Pipeline, 2009
Table 8.4 The Sleep Apnea Pharmaceutical Treatment Pipeline, 2009
List of Figures
Figure 3.1 Global Sleep Disorder Market Sales ($m), 2009-2024
Figure 3.2 Sleep Disorder Comparative Forecast in Sales ($m), 2009-2024
Figure 3.3 Sleep Disorder Comparative Forecast by Market Share (%), 2009-2024
Figure 3.4 Global Market Share (%) Comparison, 2008
Figure 3.5 Global Market Share (%) Comparison, 2024
Figure 3.6 US Sleep Disorder Market Sales ($m) to 2024
Figure 3.7 Japan Sleep Disorder Market Sales ($m) to 2024
Figure 3.8 Europe Sleep Disorder Market Sales ($m) to 2024
Figure 3.9 Emerging Markets Sleep Disorder Market Sales ($m) to 2024
Figure 4.1 Total Insomnia Market Sales ($m), 2009-2024
Figure 4.2 Ambien Sales ($m), 2009-2024
Figure 4.3 Lunesta Sales ($m), 2009-2024
Figure 4.4 Lendormin Sales ($m), 2009-2024
Figure 4.5 Imovane Sales ($m), 2009-2024
Figure 4.6 Rozerem Sales ($m), 2009-2024
Figure 4.7 Total Other Insomnia Drugs Sales ($m), 2009-2024
Figure 4.8 Comparative Insomnia Forecast in Sales ($m), 2009-2024
Figure 4.9 Comparative Insomnia Forecast by Market Share (%), 2009-2024
Figure 5.1 Total RLS Market Sales ($m), 2009-2024
Figure 5.2 Mirapex Sales ($m), 2009-2024
Figure 5.3 Requip Sales ($m), 2009-2024
Figure 5.4 Total Other RLS Drugs Sales ($m), 2009-2024
Figure 5.5 Comparative RLS Forecast in Sales ($m), 2009-2024
Figure 5.6 Comparative RLS Forecast by Market Share (%), 2009-2024
Figure 6.1 Total Wake-Promoting Market Sales ($m), 2009-2024
Figure 6.2 Provigil Sales ($m), 2009-2024
Figure 6.3 Nuvigil Sales ($m), 2009-2024
Figure 6.4 Xyrem Sales ($m), 2009-2024
Figure 6.5 Total Other Wake-Promoting Drugs Sales ($m), 2015-2024
Figure 10.1 Global Sleep Disorder Market Sales ($m), 2009-2024
Figure 10.2 Sleep Disorder Comparative Forecast Sales ($m), 2009-2024
Figure 10.3 Total Insomnia Market Sales ($m), 2009-2024
Figure 10.4 Total RLS Market Sales ($m), 2009-2024
Figure 10.5 Total Wake-Promoting Market Sales ($m), 2009-2024