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REPORT

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Neurodegenerative Disease Drug Market Analysis and Forecasts 2007

Neurodegenerative Disease Drug Market Analysis and Forecasts 2007

  • Publication date: 15/06/2007
  • Number of Pages: 188
  1. Report Details
  2. Table of Contents
  3. Companies Listed

Report Details

With the recent Alzheimer's Association International Conference suggesting a new era of hope for sufferers of the illness, drug trials have shown some enlightening discoveries.

But Alzheimer's isn’t the only neurodegenerative disease and drug possibilities in this market continue to expand. Visiongain reveal that the market value for the Neurodegenerative market was worth over $16 billion in 2006, with revenues growth anticipated to exceed $18 billion in 2007. But what will it be in 2012? This report will tell you.

This report provides comprehensive information on the neurodegenerative diseases; Parkinson's Disease, Alzheimer’s Disease, Multiple Sclerosis and Neuropathic pain. The report also covers rare genetic disorders-Huntington disease, Amyotrophic Lateral Sclerosis a niche market disease classification and also Prion diseases.

The report tackles how the significant rise in the growing population age “Baby Boom” generation, paralleled with longevity across the globe will be a major catalyst for the pharmaceutical/health care sector revenue growth in the long-term. It also analyses periods of sustained revenue growth, during 2007-2012, and how expectant patent expirations on some major blockbuster drugs with strong market shares will boost revenues in the generics market. The neurodegenerative report also sheds significant emphasis on the financial burden of the neurodegenerative diseases on national healthcares services.

Advancement in innovation in the global pharmaceutical and healthcare sector are expected to spiral global annual earnings for the major market leaders including Biogen Idec, Elan, Eli Lilly, Novartis and Pfizer.

The Visiongain Neurodegenerative Market report looks at a broad spectrum of therapies during disease treatment, including;

• Biogen Idec and Elan’s Tysabri for remitting relapsing Multiple Sclerosis
• GW’s Cannabinoid product Sativex for Multiple Sclerosis
• Eli Lilly’s Cymbalta and Pfizer’s Lyrica indication for Neuropathic pain relief.

The report answers questions such as:

- In the next 5 years what will be the successful drugs
- Is stem cell research the answer for these diseases?
- Which of the current therapies show the greatest revenue generation potential?
- How will new drug development technologies impact on neuro disorders?

Visiongain’s, Global Neurodegenerative Market Reports provides a rich insight on current research underway globally by leading industries in pharmaceutical/ Biotech sector coupled with ,unbiased market forecast, affected by views of Healthcare regulatory authorities.

Visiongain’s Global Neurodegenerative Markets provides solutions to questions search as;

• Which regions have the highest prevalence of these diseases today and by 2020?
• What market share is accounted for by individual diseases in the neurodegenerative market?
• What is the global cost of  neurodegenerative diseases and the significant market shares?
• How much the 2007 neurodegenerative market is to be valued at and what it will be worth by 2012?
• Which are the market leaders in this class of therapy?
• What are the current approved therapies in the market and are they more effective than present treatments?
• Which first line drugs will be coming off patent by 2012 and what are implications to the market?
• Which drugs have been withdrawn from the neurodegenerative market?
• Which molecules are currently in the pipelines that are deemed to answer unmet therapeutic needs in the future?

Why You Must Buy This Report:

Visiongain’s, Global Neurodegenerative Market Report, provides up-to-date analysis of present and future market illustrated by substantial number of charts and figures. It also discusses strategies employed by key players in the industries. This is a must buy report, as it will provide you with useful information on business opportunities in the big and niche markets.

The revenue forecasts generated in this report are exclusive to this report  and are determined by the market, its future prospects in terms of patent protection, generic competition, life-cycle management, licensing agreements and market activity. With in-depth primary and secondary research, the forecasts run up to 2012. It will provide you with information on the dynamics of the Neurodegenerative Disease Market, and its operation until that time.

More key questions that this report answers:

• What is the potential population treatment in the major global markets up to 2012?
• Which are the main therapeutic agents dictating the pace of the market?
• What companies are the major drivers in the market?
• What is the present market activity and are the therapies effective?
• What is the envisaged Market activity in 2012?
• How will the growing population size affect the market in 2012 (Is big pharma up to the challenge?)
• How condensed is the Neurodegenerative drug pipeline?
• What is big pharma doing to narrow unmet therapeutic demands?

Table of Contents

Chapter 1. Introducing the World Market for Neurodegenerative Disorders
 Chart 1.1 Total Revenues for Neurodegenerative Diseases ($m), 2007-2012
 Table 1.1 Overall Forecast for Neurodegenerative Diseases ($m), 2007-2012
 Chart 1.2 Market Share (%) of Neurodegenerative Diseases, 2006
 Chart 1.3 Market Share (%) of Neurodegenerative Diseases,2007

Chapter 2. Neurodegenerative Disorders
 2.1 Introduction to Neurodegenerative Disorders
 2.2 What the Global Market for Neurodegenerative Disorders tells us
 2.3 Focus of the report

Chapter 3. Parkinson's Disease
 3.1 Parkinson's Disease Overview
 3.2 Symptoms and Differential Diagnosis
 3.2.1 Tremors
 3.2.2 Bradykinesia
 3.2.3 Diagnosis
 3.3 What are the Risk Factors?
 3.3.1 Age
 3.3.2 A possible genetic basis to PD     
 3.3.3 Men are more likely to develop PD 
 3.3.4 Pesticides and Herbicides influence PD Development
 3.3.5 Reduced Oestrogen Levels increase the risk of PD
 3.3.6 Reduced Folate Levels Associated with PD
 3.3.7 Anti-oxidants
 3.4 Demographics of PD
 Chart 3.1 Projected Global Parkinson's Disease growth 2005- 2030 (m)
 Chart 3.2 Projected Parkinson's Disease Growth In 2030, by Region (%)
 Chart 3.3 Parkinson's Disease Global Market Share in 2005
 3.5 Financial Burden of PD
 3.6 Pathophysiology of PD
 3.7 The Market Profile of PD
 3.8 Current Pharmaceutical Therapies of PD
 Table 3.1 Current pharmaceutical therapies available for Parkinson's Disease
 Table 3.2 Other Medications available for Parkinson's Disease
 3.9 Dopamine Precursors as the Standard Treatments for PD
 3.9.1 Sinemet (Co-Careldopa)
 Chart 3.4 Sinemet Revenue forecast 2007-2012
 Table 3.3 Sinemet Revenue Forecast for 2007-2012
 3.9.2 Madopar (Co-benelopa)
 Chart 3.5 Madopar Revenue forecast 2007-2012
 Table 3.4 Madopar Revenue Forecast for 2007-2012
 3.9.3 Carbidopa and Benserazide
 3.10 Dopamine Agonists as Treatments for PD
 3.10.1 Ergot-Alkaloid-Based Agents
 3.10.2 Parlodel (Bromocriptine)
 Chart 3.6 Parlodel Revenue 2001-2006
 3.10.3 Dopergine (Lisuride) is Superior to Parlodel
 3.10.4 Permax (Pergolide)
 Chart 3.7 Permax Revenue before withdrawal 
 3.11 Apomorphine as Additional Relief for PD Sufferers
 3.11.1 Requip (Ropinirole)
 Chart 3.8 Requip Revenue forecast 2007-2012
 Table 3.5 Sinemet Revenue Forecast for 2007-2012
 3.11.2 Sifrol/Mirapexin (Pramipexole) is the Most Successful Drug in PD
 Chart 3.9 Sifrol Revenue forecast 2007-2012
 Table 3.6 Sifrol Revenue Forecast for 2007-2012
 3.12 N-Methyl-D-Asparate Receptor Antagonists (NMDA)
 3.13 Symmetrel (Amantadine)
 3.14 AMPA alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid Receptor Antagonist
 3.14.1 Talampanel
 3.15 COMT (Catechol-O-methyl transferase) Inhibitors
 3.15.1 Tasmar (Tolcapone) as an Adjunct Therapy
 3.15.2 Comtess (Entacapone) to Aid PD Treatment
 Chart 3.10 Comtan Revenue forecast 2007-2012
 Table 3.7 Comtan Revenue Forecast for 2007-2012
 Chart 3.11 Comtess Revenue forecast 2007-2012
 Table 3.8 Comtess Revenue Forecast for 2007-2012
 3.16 Dopamine and COMT combined
 3.16.1 Stalevo - the combination therapy
 Chart 3.12 Stalevo Revenue forecast 2007-2012
 Table 3.9 Stalevo Revenue Forecast for 2007-2012
 3.17 Anticholinergics (Antimuscarinic drugs)
 3.17.1 Congentin (benzatropine mesilate)
 3.17.2 Artane (Trihexyphenidyl) to Control Common Symptoms
 3.18 Antihistamines and Antidepressants Can aid PD Symptoms?
 3.19 Monoamine Oxidase B Inhibitors
 3.19.1 Deprenyl (Selegeline)
 3.20 The World Market for PD Drugs in will show significant growth to 2012
 Table 3.10 Revenue forecasts for selected PD drugs 2007-2012
 Chart 3.13 Total Global Parkinson’s Disease market forecast 2007-2012  
 Table 3.11 Total Global Parkinson’s Disease market forecast 2007-2012
 3.21 Surgical Therapy is not a Popular Treatment of PD
 3.21.1 Thalamotomy only used to Reduce Tremors
 3.21.2 Pallidotomy is becoming more popular as a Treatment for PD
 3.21.3 Deep Brain Stimulation aids in Tremor Reduction
 3.22 Emerging therapies for Parkinson's Disease
 3.22.1 ALS Drug, Rilutek (Riluzole), to Help PD Patients
 3.22.2 HD Treatment, Remacemide(Remacemide hydrochloride), for PD
 3.22.3 Rasagiline
 3.22.4 Azilect (Rasagiline)
 3.23 Other New Drugs in Development
 3.23.1 The process of Apoptosis in Parkinson's Disease
 3.23.2 Pig Neuron Implantations as new Treatments for PD
 3.23.3 A Nerve Growth Promoter may have a Role in PD Treatment
 3.23.4 The Implantation of Dopamine Producing Cells as a Novel Therapy in PD
 3.23.5 GDNF Gene Therapy as a new Treatment Therapy
 3.23.6 Biogen Idec and Vernalis Phase II BIIB014 oral compound
 3.23.7 Subcutaneous drug delivery system underway for treatment of PD
 3.23.8 Neuroprotective agent PD 02 slows PD progression in phase II trials
 3.23.9 Newron's safinamide effective in early and late-stage Parkinson's disease
 3.23.10 Signalling Ret-receptors protect the live of nerve cells in the aging brain
 3.24.1 Parkinson's patch approved in Europe for all stages of Parkinson's disease
 3.24.2 Neurologix completes Phase I GAD gene therapy trial for Parkinson's disease.
 3.24.3 Ceregene in a Phase I Neurturin gene therapy study
 3.24.4 Arundic acid an astrocyte modulating agent for PD
 3.24.5 Antioxidative properties of Vitamin E, C and health food
 3.24.6 Coenzyme Q10 potential antioxidant

Chapter 4. Alzheimer's Disease
 4.1 Introduction
 4.2 Symptoms and Differential Diagnosis
 4.2.1 Using brain scans to detect Alzheimer's
 4.3 The Risk Factors for AD
 4.4 The Demographics for AD
 Chart 4.1 Prevalence of Alzheimer's Diseases
 Chart 4.2 Prevalence of Alzheimer's Diseases After Every Five Years
 4.5 Financial Burden of AD
 Chart 4.3 Projected Growth of Alzheimer's Diseases in the USA by 2050 (m)
 4.4 Global Sufferers of Alzheimer's Diseases in 2005, 29.3 Million
 Chart 4.5 Global Cost of Alzheimer's Diseases, 2003-2005 ($m)
 4.6 Type of Protein as a Cause for AD?
 4.6.1 Neuronal and Synaptic Loss of AD
 4.6.2 Chromosomal Mutations of AD
 4.6.3 Inflammation of AD
 4.7 Current AD Pharmaceutical Drug Therapies
 4.8 Acetylcholinesterase Drugs - How do you Treat Mild to Moderate AD?
 4.8.1 Cognex (Tacrine)
 4.8.2 Aricept (Donepezil hyrdochloride) - The leading drug choice for AD
 4.8.3 Excelon (Rivastigamine) - Popular Drug Therapy for AD
 Table 4.1 Aricept Revenue forecast 2007-2012
 Chart 4.7 Aricept Revenue forecast 2007-2012
 4.8.4 Reminyl (Galantamine) is a Minor Treatment for AD
 4.9 Ebixa (Namenda) The Drug Treatments for Moderate to Severe AD
 Chart 4.8 Reminyl revenue forecast 2007-2012
 Table 4.2 Reminyl revenue forecast 2007-2012
 4.10 Non steroidal anti-inflammatory drugs (NSAID)
 4.11 The AD drug Market
 Chart 4.10 Overall  Market Forecast for Alzheimer's Disease, 2007-2012
 Table 4.4 Overall Market Forecast for Alzheimer's Disease, 2007-2012
 Chart 4.11 Market share for leading AD drugs, 2006
 4.11.1 Will the Major AD drugs continue to dominate the Market?
 4.11.4 Leading Cholinesterase inhibitors in the AD market
 4.11.5 US Dominates the World AD Market
 4.12 Emerging Therapies for Alzheimer's Disease
 4.12.1 Vitamin E (Antioxidants) for AD
 4.12.2 Research has revealed that Vitamin E, Vitamin C and other health foods do possess their oxidative   properties.
 4.12.3 OTC Ginko Biloba May Slow AD Symptoms
 4.12.4 Oestrogen HRT May Protect Against AD
 4.12.5 Nicotine Replacement Therapy as a Potential Treatment for AD
 4.13 Future Therapies for Alzheimer's Disease will not overrule conventional drug therapies
 4.14 The Future Market for Alzheimer's Disease
 4.15 Pipeline Drugs for AD
 4.15.1 PBT-1 (Coloquinol)
 4.15.2 Alzhemed
 4.15.3 Phenserine
 4.15.4 Allon Therapeutics'AL-108 and AL-208 to inhibit neuronal death
 4.15.5 Martek's DHA reduces brain lesions in AD animal models
 4.16 The Future of the AD Drug Market

Chapter 5. Multiple Sclerosis
 5.1 Introduction
 5.2 The different categories of MS 
 5.2.1 Benign MS
 5.2.2 Relapse-remitting MS
 5.2.3 Primary progressive MS
 5.2.4 Secondary progressive
 5.2.5 Progressive relapsing MS
 5.3 Symptoms and Differential Diagnosis
 5.3.1 Primary symptoms
 5.3.2 Secondary symptoms
 5.3.3 Tertiary symptoms  
 Table 5.1 Summary of Multiple Sclerosis Symptoms
 5.3.4 Diagnosis of MS
 5.4 The Risk factors of MS
 5.4.1 Immunologic Factors
 5.4.2 Environmental Effects may influence MS Incidence
 5.4.3 The Viral Induction of MS is possible
 5.4.4 The Genetic Basis of MS Exists
 5.4.5 Hormones Presidspose Women to MS
 5.5 The Demographics of MS
 Chart 5.1 The Global Dermographics of MS,2007
 5.6 Current Pharmaceutical Drug Therapies
 5.7 Relapsing-Remitting MS
 5.7.1 Avonex (Interferon beta 1a) to Reduce Severity of MS
 5.7.2 Rebif (Interferon beta 1a)
 5.7.3 Betaseron (Interferon beta 1b)
 5.7.4 Copaxone (Glatiramer acetate)
 5.8 Antineoplastic Drugs [Relapse-Remitting & Secondary progressive]
 5.8.1 Cancer Drug, Novantrone (Mixonatrone) Benefits  MS Sufferers
 Table 5.3  Novantrone revenue Forecast 2007-2012
 Chart 5.3 Novantrone Revenue Forecast 2007-2012
 5.9 Taxanes
 5.9.1 Taxol (paclitaxel)
 5.10 Immunosuppressants - Secondary Progressive and Worsening Relapse-Remitting MS
 5.10.1 Imuran (Azathioprine)
 5.10.2 Sandimmune (Cyclosporine)
 5.11 Corticosteroids
 5.12 Muscle Relaxants
 5.13 Market Analysis of Multiple Sclerosis
 5.13.1 Avonex remains the leading MS drug
 Chart 5.4  Avonex revenue forecast 2007-2012
 Table 5.4  Avonex revenue forecast 2007-2012
 Chart 5.5 Copaxone revenue forecast 2007-2012
 Table 5.5 Copaxone revenue forecast 2007-2012
 Chart 5.6  Rebif Revenue Forecast, 2007-2012
 Table 5.6  Rebif Revenue Forecast, 2007-2012
 Chart 5.7 Betaferon revenue forecast 2007-2012
 Table 5.7 Betaferon revenue forecast 2007-2012
 Chart 5.8 Overall MS Market Forecast For 2007-2012
 Table 5.8 Overall MS Market Forecast for 2007-2012
 Table 5.9 Market Share of Major MS drugs 2005-2006                
 Chart 5.9 Market Share of Major MS drugs 2005-2006
 5.13.1 Current Drugs approved in the MS Market
 5.13.1.1 Elan /Biogen Idec Tysabri (natalizumab) for remitting relapse MS
 5.13.1.2 Tysbri will dominate MS market share during 2007-2012
 Chart 5.10 Tysabri Revenue Forecast 2007-2012
 Table 5.10 Tysabri Revenue Forecast 2007-2012
 5.13.1.3 GW Sativex Investigational Cannabis-Based Treatment for MS
 5.14 Pipeline drugs
 5.14.1 Oral drugs development for MS
 5.14.1.1 Serono's Mylinax (oral formulation)
 5.14.1.2 Novartis's Fingolimod (FTY720)
 5.14.1.3 Sanofi-Aventis's Teriflunomide
 5.14.1.4  Pfizer's Lipitor (atorvastin)
 5.14.1.5  Active Biotech's Laquinimod
 5.14.2 Progressive forms of MS studies underway
 5.14.2.1 Genetech Rituxan
 5.14.2.2 Bayhill Therapeutics BHT-309
 5.14.2.3 BioMS synthetic fragment 
 5.14.2.3 MS Society funded Oral against Inhaled cannabis study
 5.14.3 Other studies underway include extending the indications of therapies approved by the FDA to treat   MS.
 5.14. Leustat (Cladibrine)
 5.15 Experimental Treatment for Multiple Sclerosis 
 5.15.1 Gene Therapy
 5.15.2 Plasmapheresis (plasma exchange)
 5.15.3 Intravenous Immunoglobin (IVIg)
 5.15.4 Oligodendrocyte Implants

Chapter 6. Huntington's Disease
 6.1 Introduction
 6.2 Aetiology of HD
 6.3 Symptoms and Differential Diagnosis of HD
 6.3.1 Early Symptoms
 6.3.2 Advanced Symptoms
 6.4 Demographics of HD
 6.5 Pathophysiology of HD
 6.6 Current Pharmacological Treatment for HD
 6.7 Chorea Controlled by Benzodiazepines
 6.8 Dopamine Antagonists can help HD patients
 Chart 6.1 Haldol Revenue 2003-2006
 6.8.1 Cannabinoids to Ease Symptoms of HD
 6.9 Monoamine-depleting agents
 Chart 6.2 Nitoman Revenue Forecast,2007-2012
 Table 6.1 Nitoman Revenue Forecast,2007-2012
 6.10 Prospects for Future Treatment
 6.10.1 Cystamine to reduce symptoms
 6.10.2 HDAC Inhibitors may serve as a potential cure for HD
 6.10.3 Avicena HD-02 novel candidate for HD
 6.10.4 Ubiquitin proteasome systems in HD
 6.10.5 Other potential HD therapies
 6.10.6 Riluzole (Rilutek)
 6.10.7 Antioxidants contribute to future treatment of HD
 6.11.0 The Case for Stem Cells
 6.11.1 Working on Neurotrophic Factors for HD
 6.11.2 Regeneron and Medtronic collaborate on Axokine
 6.11.3 Evaluation of SIRT1 Inhibitors in Huntington's disease
 6.11.4 Antibiotic Minocycline may have a Role in HD Treatment
 6.11.5 Amarin Miraxion in HD
 6.11.6 Gene Therapy model in HD
 6.12 Market opportunities in HD


Chapter 7. Amyotrophic Lateral Sclerosis 
 7.1 Introduction
 7.2 The Progression of ALS
 7.3 Risk Factors of ALS
 7.4 The Diagnosis of ALS
 7.5 The Demographic Impact of ALS
 Chart 7.1 Global Dermographics of ALS
 7.6 What are the Treatment Options for ALS?
 7.6.1 Rilutek (riluzole)
 Chart 7.2 Riluzole Revenue Forecast,2007-2012
 Table 7.1 Riluzole Revenue Forecast,2007-2012
 7.6.2 The Pharmacological Treatment for Symptom Relief of ALS
 7.6.3 Neurontin (Gabapentin)
 7.6.4 Topamax (Topiramate)
 7.7 Pipeline Drugs for ALS
 7.7.1 Creatine Monohydrate
 7.7.2 CEP 1347 (Cephalon's mixed-lineage kinase inhibitor)
 7.7.3 Xaliproden Hydrochloride to Regenerate NF
 7.8 Can a Cure for ALS be Found?
 7.8.1 Neurotrophic Factors
 7.8.2 The Role of Apoptosis in ALS
 7.8.3 Biological Markers for ALS
 7.8.4 Gene Research in ALS
 7.8.5 The Antibiotic Minocycline may have a Role in ALS Treatment
 7.8.6 Cox-2 (Nimesulide)

Chapter 8. Neuropathies
 8.1 Introduction
 8.2 Causes of Neuropathy
 8.3 The Symptoms of Neuropathy
 8.4 Who is at Risk?
 8.5 Diagnosis of Neuropathy
 8.6 The Classifications of Neuropathy
 8.6.1 Diabetic Neuropathy
 8.6 The Classifications of Neuropathy
 8.6.1 Diabetic Neuropathy
 8.6.2 Auto-immune Disease and its Relationship with Neuropathic Pain
 8.6.3 Chemotherapy-Induced Neuropathy
 8.6.4 Drug-Related Neuropathy
 8.7 The Societal Impact of Neuropathy
 Chart 8.1 Global Demographics of Neuropathetic Pain
 8.8 The Cost of Neuropathic Pain
 8.9 The Current Treatment of Neuropathy
 8.10 Non-pharmaceutical Treatments and Therapies for Neuropathic Pain
8.11 The Major Current Pharmaceutical Treatment for Neuropathy
8.11.1 Topical Agents
8.11.2 Pfizer's Lyrica an approved therapy for peripheral neuropathic pain
 Table 8.1 Lyrica Revenue Forecast, 2007-2012
 Chart 8.2 Lyrica Revenue Forecast, 2007-2012
 8.11.3 Lilly's Cymbalta an approved therapy for peripheral diabetic neuropathy (PDN)
 Table 8.2 Cymbalta Revenue Forecast,2007-2012
 Chart 8.3 Cymbalta Revenue Forecast,2007-2012
 Chart 8.4 Teva (Neurontin) Revenue Forecast, 2007-2012
 Chart 8.5 Pfizer (Neurontin) Revenue Forecast, 2007-2012
 Chart 8.6 Actavis (Neurontin) Revenue Forecast,2007-2012
 Chart 8.7 Apotex (Neurontin) Revenue Forecast,2007-2012
 Chart 8.8 Pharmascience (Neurontin) Revenue Forecast,2007-2012
 Table 8.3 Neuopathy Revenue Forecast,2007-2012
 Chart 8.9 Neuropathy Revenue Forecast,2007-2012
 8.12.1 Pain relievers
 8.11.2 Antidepressants
 Table 8.4 Common Antidepressants Used In Treating Neuropathiese
 8.11.3 Anticonvulsants
 8.12.4 Antiarrhythmics
 8.12.5 Analgesics
 8.12.6 Opioids Maintaining Relief for Neuropathy
 8.12.7 Morphine
 8.12.8 Duragesic (Fentanyl)
 8.12.9 Oxycontin (Oxycodone)
 8.13 Other Drugs Used in Neuropathies
 8.13.1 Mexitil (Mexiletine)
 8.13.2 Methycobal (Mecobalamin)
 8.13.3 Tramadol
 8.14 Current Developments: New Anticonvulsants
 8.14.1 Topamax (Topiramate) - An indication of Topamax in Neuropathic Pain will see Revenues Rise
 8.14.2 Lamictal (Lamotrigine) - Anti-Epileptic Lamictal may be Indicated for Neuropathic Pain
 8.14.3 Keppra (Levetiracetam)
 8.15.1 Thioctic Acid
 8.15.2 Topical QR-333 a potential compound for diabetic neuropathy
 8.15.3 Allon Therapeutics  AL-108 and AL-208 Molecules to inhibit neuronal death
 8.15.4 Biovitrum commence Phase II trials
 8.15.5 Brane Potential Blockbuster drug
 8.16 Growth Factors may have a Role in Neuropathic Pain
 8.17 NMDA Antagonists
 Table 8.4 Other Current Developments in Neuropathic Drugs, 2007
 

 

Chapter 9. Prion Diseases
 9.1 Introduction
 9.2 CJD
 9.2.1 What is it?
 9.2.2 The Aetiology of CJD
 9.3 Varying Types of CJD
 9.3.1 Sporadic or classical CJD
 9.3.2 Hereditary or familial CJD
 9.3.3 Acquired or iatrogenic aCJD
 9.3.4 (Variant) vCJD
 Table 9.1 Number of suspect cases referred to CJD surveillance unit in Edinburgh and other reported cases in the   UK
 9.4 Demographics of CJD
 9.5 Symptoms of CJD
 9.5.1 Initial symptoms
 9.5.2 Progressive symptoms
 9.5.3 End-stage symptoms
 9.6 Diagnosis of CJD
 9.7 Treatments of CJD
 9.8 The Political issues attached to CJD
 9.9 Gerstmann-Straussler-Scheinker Syndrome (GSS)
 9.9.1 What is it?
 9.9.2 Aetiology of GSS
 9.9.3 Symptoms of GSS
 9.9.4 Demographics of GSS
 9.10 FFI
 9.10.1 What is it?
 9.10.2 Aetiology of FFI
 9.10.3 Symptoms of FFI
 9.10.4 Diagnosis of FFI
 9.10.5 Demographics of FFI
 9.10.6 Stages of FFI
 9.10.7 Treatment
 9.11 Kuru
 9.11.1 What is it?
 9.11.2 Symptoms of Kuru
 9.11.5 Demographics of Kuru
 9.11.6 Treatment of Kuru
 9.11.7 Future Research for Kuru
 9.12 Alper's Syndrome
 9.12.1 What is it?
 9.12.2 Aetiology of Alper's
 9.12.3 Symptoms of Alper's
 9.12.4 Primary symptoms of Alper's
 9.12.5 Secondary symptoms of Alper's
 9.12.6 Treatment for Alper's Syndrome
 9.12.7 Prognosis of Alper's syndrome
 9.12.8 What research is being done?

Chapter 10. Summary of the Neurodegenerative Market

Companies Listed

Abbott Laboratories
Actavis
Active Biotech
Alliance
Allon Therapeutics
Alpharma
Alza
Amarin Corporation
Amgen
Apotex
Astellas
AstraZeneca
Avicena
Bayhill Therapeutics
Berlex
Biogen Idec
BioMS Medical
Biovitrium
Boehringer Ingelheim
Brane Discovery
Bristol-Myers Squib
Britannia
Buck Institute for Age Research
Caraco Pharmaceutical Laboratories
Cephalon
Ceregene
Chiesi
Cognetix
Core Pharma
DepoMed
Diacin
Elan
Eli Lilly
Elixir Pharmaceuticals
EMEA
Endo Pharmaceuticals
EpiCept
Esai
First Horizon
Food and Drug Administration
Forest
Genentech
Genzyme
GSK
Guilford
GW Pharmaceuticals
H Lundbeck
Impax
IVAX
Janssen-Cilag
Johnson & Johnson's
Journal of Alzheimer's & Dementia
Journal of Neurochemistry
Karoliska Institute
Labopharm
Max Planck Institute of Neurobiology
Medtronic
Merck & Co
MHRA
MS Society
MSD
Mutual Pharmaceutical
Myelos Neuroscience
Mylan
National Academy of Sciences
National Institute of Aging
National Institute of Neurodegenerative Diseases and Stroke
National Prion Clinic
Neo Therapeutics
Neurobitotic
Neurochem
NeurogesX
Neurologix
NeuroSearch
Newron
Novartis
Orion
Otsuka
Pharmaceuticals
PCC Naturals
Pfizer Pharmacia (Pfizer)
PharmaNova
Pharmascience
Polymun
Prana Technology
Prestwick
Prometheus
Purdue
Pharma
Quigley
Pharma
Regeneron
Rhone
Poulenc
Rorer
Rinat
Roche
Rorer Pharm
Sanochemia
Sanofi-Aventis
SantoSolve
Schering (Bayer Schering)
Schwarz Pharma
Serono
Shire
Siena Biotech
Stanford University
Takeda Chemical
Teva
The New England Journal of Medicine
UCB Pharma
UK medical research council
University of Roches
Valeant
Vernalis
Vertex
VistaGen
WHO
Wyeth
Xenoport